| Title |
Breast carcinoma in situ types, diagnostics, treatment and prognosis / |
| Translation of Title |
Breast Carcinoma in Situ Types, Diagnostics, Treatment and Prognosis. |
| Authors |
Senkel, Charis Sophia Christina |
| Full Text |
|
| Pages |
46 |
| Keywords [eng] |
Ductal carcinoma in situ, Lobular carcinoma in situ, Lobular neoplasia, Risk stratification, Overtreatment |
| Abstract [eng] |
Ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS) represents premalignant diseases of the breast, typically localized in the milk ducts or in the terminal ducto-lobular unit. In difference to an invasive breast carcinoma there is no invasion of the basement membrane. While DCIS is considered as a precursor of invasive breast cancer, LCIS is a risk factor for breast cancer. Since implementation of mammography screening program the incidence of DCIS and LCIS has significantly increased. Both lesions, DCIS and LCIS, comprises a variety of heterogeneous subtypes with wide range of histomorphology, genetic abnormalities, biomarker expression profile and biological and clinical potential. The goal of therapy management with surgery, radiation therapy and endocrine therapy is to prevent local recurrence and progression to invasive disease. This is increasingly a great challenge to understand the natural history of in situ lesions and to find intelligent therapy concepts. This review presents a summary for better understanding the heterogeneity of DCIS and LCIS and should show the current therapy management of these diseases. It highlights the need for de-escalation of therapy, especially for low-grade DCIS and LCIS variants to avoid over- and undertreatment. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Master thesis |
| Language |
English |
| Publication date |
2023 |
