| Abstract [eng] |
Objective. To determine the risk factors for severe COVID-19 in patients hospitalised in Vilnius University Hospital Santaros Clinics. Methods. The analysis included medical data of COVID-19 patients hospitalised in Vilnius University Hospital Santaros Clinics between March 2020 and December 2021. Demographic, clinical, and laboratory parameters of the subjects at the time of hospitalisation were analysed. Statistical analysis was performed using SPSS 23.0 software. Results. The study included 495 subjects, 233 (47.07 %) were women. The median age of the patients was 55 (IQR 43-65) years. Significant odds ratios for risk factors were found: age 65 years (OR 2.05, 95 % CI [1.34-3.15]), male sex (OR 1.55, 95 % CI [1.08-2.22]), obesity (OR 3.58, 95 % CI [1.96-6.56]), COPD (OR 9.49, 95 % CI [1.23 - 73.15]), arterial hypertension (OR 2.11, 95 % CI [1.46 - 3.03]), other cardiovascular disease (OR 1.83, 95 % CI [1.15 - 2.92]). Symptoms during hospitalisation were found to increase the odds of severe disease: febrile fever (OR 3.13, 95 % CI [1.84 - 5.33]), tachypnoea (OR 3.56, 95 % CI [1.48 - 8.54]), malaise (OR 2.77, 95 % CI [1.56 - 4.91]), cough (OR 1.69, 95 % CI [1.00 - 2.85]), dyspnoea (OR 3.23, 95 % CI [1.91 - 5.45]). Predictive laboratory tests for severe course of COVID-19: CRP (AUC=0.81), LDH (AUC=0.84), AST (AUC=0.77), D-dimers (AUC=0.73) and ferritin (AUC=0.78). Conclusions. Older age, male sex, obesity, COPD, arterial hypertension, other cardiovascular disease, and obesity as a risk factor, increase the odds of developing severe COVID-19 disease. Predictors of severe COVID-19 disease include febrile fever, tachypnoea, general weakness, cough, and dyspnoea. Severe disease is predicted by elevated CRP, LDH, AST, ferritin, and D-dimer values. |
