| Title |
The role of microbiome in parkinson‘s disease / |
| Translation of Title |
The Role of Microbiome in Parkinson‘s Disease. |
| Authors |
Bereisha, Michael |
| Full Text |
|
| Pages |
19 |
| Keywords [eng] |
Parkinson’s Disease, Microbiome, Alpha-Synuclein, Fecal Microbiota Transplant (FMT), Antibiotics, Short Chain Fatty Acids, Probiotics |
| Abstract [eng] |
Environmental aspects of a person’s life can define their personalities as well as their microbiomes. In turn, the microbiome can be the key to a person’s ongoing health throughout their whole lives. This review seeks to examine the key pathways that connect the microbiome to the central nervous system as well as the microbiological therapies that may aid in treating Parkinson’s disease. Detailed examination of the interplay between the connections of human biology and microbiology elucidates that disturbances in the microbiome can not only influence the development of neurodegenerative diseases but outright cause them via retrograde synaptic proliferation of alpha-synuclein aggregates and inflammatory insult bypassing the critical protective barriers of the body. Furthermore, clinical evidence has shown that treatment strategies like Fecal Microbiota Transplant, Immune-modulating antibiotics, and Probiotics are all effective at preventing and treating symptoms related to Parkinson’s disease and, with refinement, may become mainstays in clinical treatment. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Master thesis |
| Language |
English |
| Publication date |
2022 |
