| Abstract [eng] |
Objective: To assess the relationship between laboratory parameters and risk factors in the middle-aged Lithuanian population with metabolic syndrome. Material and methods: In the period 2012 to 2019, 5554 subjects who participated in the primary cardiovascular disease prevention program were sent for examination to the Vilnius University Hospital Santaros Klinikos Preventive Cardiology subdepartment due to metabolic syndrome or diabetes diagnosis. Subjects underwent laboratory tests of blood lipids, fasting glycaemia, high-sensitivity C-reactive protein, uric acid, and glomerular filtration rate and their risk factors were evaluated. Results: The most common risk factors in the study population were dyslipidaemia, primary arterial hypertension, obesity, family history, and smoking, exclusively in men. Using multiple linear regression models, smoking, female gender, and diastolic arterial blood pressure were found to have the greatest impact on total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol. Low levels of high-density lipoprotein cholesterol were significantly associated with obesity, while high levels of triglycerides were affected by smoking and the incidence of microalbuminuria or diabetes. The majority of risk factors were associated with high-sensitivity C-reactive protein. An association was observed with increased waist circumference, obesity, smoking, and a significant reduction in high-sensitivity C-reactive protein was observed when using lipid-lowering drugs. Higher glucose concentrations were common in individuals with microalbuminuria. The uric acid concentration was associated with waist circumference and higher diastolic arterial blood pressure. Higher glomerular filtration rates were observed in smokers depending on their age. Conclusions: This study found a high prevalence of risk factors in the population with metabolic syndrome. A significant association between evaluated laboratory parameters and most risk factors was found, most notably with smoking, obesity, high diastolic arterial blood pressure, and female gender. |
