| Abstract [eng] |
Aim of the review. To determine the prevalence and association of autoimmune diseases and vitamin D deficiency with psoriasis and its severity in the recent scientific literature. Objectives: 1. To evaluate the prevalence of autoimmune diseases (autoimmune thyroiditis, inflammatory bowel disease, celiac disease, ankylosing spondylitis, rheumatoid arthritis, psoriatic arthritis, Bechet’s disease, systemic lupus erythematosus, Sjӧgren’s disease, systemic sclerosis, dermatomyositis / polymyositis) among psoriasis patients. 2. To compare the prevalence of autoimmune diseases between psoriasis patients and healthy individuals. 3. To evaluate the association between the onset autoimmune diseases and the severity of psoriasis. 4. To assess the prevalence of vitamin D deficiency among patients with psoriasis. 5. To compare the prevalence of vitamin D deficiency between psoriasis patients and healthy individuals. 6. Assess the association of vitamin D deficiency with the severity of psoriasis. Methods. The search for publications was conducted in 2022, February – March, using the PubMed (Medline) medical database. Keywords and their combinations used to search for the publications: "psoriasis", "autoimmune disease", "vitamin d", "inflammatory bowel", "multiple sclerosis", "lupus erythematosus", "autoimmune thyroiditis", "hashimoto thyroiditis", "graves disease”, “coeliac disease”, “crohns disease”, “ulcerative colitis”, “addisons disease”, “sjogrens syndrome”, “prevalence”, “association”. Filters used in the database: Full text, Clinical Study, Clinical trial, Comparative study, Controlled clinical Trial, Observational Study, Randomized Controlled Trial, 10 years, English. Results. A total of 382 articles were found. 10 publications met the set criteria and were included in the review. Six publications described the prevalence of autoimmune diseases and four described vitamin D deficiency. All studies showed a higher prevalence of autoimmune diseases in the psoriasis group compared to the general population. Studies of serum vitamin D in psoriasis patients have yielded controversial results, with only two of the four publications included in this review finding an association between vitamin D deficiency and psoriasis independent of factors such as gender, age, body mass index, psoriasis area and severity index, parathyroid serum concentration, skin phenotype, time spent in direct sunlight, nutrition. The other two authors did not find a correlation between the psoriasis and vitamin D deficiency. Conclusions: 1. The prevalence of autoimmune diseases (autoimmune thyroiditis, inflammatory bowel disease, celiac disease, ankylosing spondylitis, rheumatoid arthritis, psoriatic arthritis, Bechet's disease, systemic lupus erythematosus, Sjӧgren's disease, systemic sclerosis, dermatomyositis / polymyositis) among psoriasis patients is high. 2. The prevalence of autoimmune diseases among psoriasis patients is higher than in healthy individuals. 3. Patients with severe psoriasis are at increased risk of developing autoimmune diseases. 4. The prevalence of vitamin D deficiency is high among people with psoriasis. 5. The prevalence of vitamin D deficiency is higher among people with psoriasis than in healthy individuals. 6. There is insufficient evidence to suggest that vitamin D deficiency results in a more severe course of psoriasis. |
