| Abstract [eng] |
Object. Obstructive sleep apnea (OSA) – is a common sleep disorder characterized by recurrent episodes of apneas and / or hypopneas that can occur in different sleep stages: rapid eye movement (REM) or non-rapid eye movement (non–REM). The goal of this study was to compare the severity of the disease, association with comorbid diseases, lifestyle factors and functional outcomes after treating with positive airway pressure (PAP) therapy between REM and non–REM associated OSA patients of Vilnius University Hospital Santaros Klinikos Center of Pulmonology and Allergology. Methods. 109 patients took part in this retrospective study (78 men and 31 women) whose mean age was 54 ± 13 years. Based on polysomnography results, they were all diagnosed with OSA and then, using software filters, the exact phenotype of OSA was confirmed – REM or non-REM. Patient demographic, anthropometric and polysomnographic features were compared for different phenotypes of OSA. Results. The patients with REM – related OSA (7.3 % of all patients) had significantly lower apnea - hypopnea index (AHI) (36.1 ± 11.1 events/h vs. 49.6 ± 24.2 events/h, p = 0.012), non-supine AHI (15.9 ± 7.1 events/h vs. 39.5 ± 28.8 events/h, p = 0.003), oxygen desaturation index (ODI) (27.0 ± 16.7 events/h vs. 41.9 ± 25.0 events/h, p = 0.043) and Charlson Comorbidity index (0.5 ± 0.6 vs. 1.8 ± 1.6, p = 0.011) compared with non-REM – related OSA patients. There were no significant differences comparing age, body mass index (BMI), supine AHI, Epworth Sleepiness Scale scores, systolic and diastolic blood pressure in different phenotypes of OSA. Conclusion. REM–related obstructive sleep apnea is not a common phenotype of OSA. This phenotype is more specific for patients with mild symptoms and is less associated with comorbid diseases. CPAP therapy is equally effective for both stages (REM and non-REM – related) of OSA. |
