| Abstract [eng] |
This literature aims to present different mechanisms of malignancies as a comorbidity in rheumatic diseases and mechanisms of the development of rheumatic syndromes in cancer patients. Cancer poses a major threat to public health worldwide and is one of the leading causes of death with increasing incidence rates since 1990. Rheumatic diseases are highly prevalent in the general adult population and associated with significant morbidity and therefore pose a major burden for the patients. Due to the bidirectional relationship of both disease entities, there is a high interest in understanding the processes behind these relations. An electronic search on the online databases PubMed and Google Scholar was performed covering up until March 2022. The time limit was set for papers, which were published not later than 2017. The computerized search was complemented with a manual one of the reference lists of the retrieved articles. Rheumatic diseases and malignancies are related in a bidirectional manner. Malignancies can be either directly or indirectly related to various rheumatic diseases. Paraneoplastic syndromes may also resemble rheumatic diseases. Additionally, Immune checkpoint inhibitors commonly cause immune related adverse effects, which may resemble various rheumatic diseases. Patients with prostate cancer, who are receiving androgen deprivation therapy are at an increased risk for osteoporosis. It is important to conduct more research about the relationship of rheumatic diseases and malignancies as many of the mechanisms are not yet understood. |
