| Title |
Coronary syndrome in children with inflammatory heart disease / |
| Translation of Title |
Coronary Syndrome in Children with Inflammatory Heart Disease. |
| Authors |
Valdman, Kristin Merie Ann |
| Full Text |
|
| Pages |
24 |
| Keywords [eng] |
Kawasaki disease, Echocardiography, Corticosteroids, Coronary artery disease, Aspirin, Intravenous immune globulin, Aneurysm |
| Abstract [eng] |
Introduction Kawasaki disease (KD) is the leading cause of acquired coronary artery disease in children, typically presents in children below the age of 5 years. The male gender is more prone to the disease than the females. The standard treatment method is intravenous immunoglobin. The treatment can have shortcomings, and the main one is the development of coronary artery disease. Methods A systematic search of online databases was helpful for the systematic review. The databases include Cochrane Central Register of Control, PubMed, Science Direct, Web of Science, and EMBASE. Scrutiny was through thorough eligibility criteria that did not comprise the publishing year. The study included articles from different years. Results The search produced 940 articles which included various meta-analyses and systematic reviews. After going through the eligibility criteria, the appropriate Randomized Controlled Trials were forty. The other articles discussed non-relevant issues, and others were duplicates. The result of the systematic review indicates that IVIG resistant patients are at a higher risk for developing coronary lesions and aneurysms. Conclusion Intravenous immunoglobulin (IVIG) therapy is the main treatment principle for Kawasaki condition. In some patients, IVIG may lead to the development of coronary artery lesions, which might be associated with IVIG therapy resistance. There is subsequent research to curb the shortcoming by combining different treatment methods. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Master thesis |
| Language |
English |
| Publication date |
2022 |
