| Abstract [eng] |
In this work, the influence of the alertness level on the loudness dependence of auditory evoked potentials LDAEP was evaluated. Loudness dependence of auditory evoked potentials (LDAEP) is a widely used EEG-based biomarker of central serotonergic activity. LDAEP is considered a reliable non-invasive indicator of central serotonin function. Serotonin regulates a number of biological processes, including cardiovascular function, intestinal motility, and bladder control. Disorders of serotonin metabolism are strongly associated with the onset of depression. It is one of the most common mental disorders in outpatient clinics and for individuals seen in various fields of medicine and surgery. Due to the low serotonergic neurotransmission, there is a marked increase in the amplitude of the N1 / P2 component with increasing stimulus intensity and vice versa. The aim of this work is to determine what level of vigilance should be desired when establishing LDAEP (eyes closed or open), as it is so often overlooked, omitted, ignored in the literature. An experiment was conducted with university students who performed tests for general anxiety and depression prior to the LDAEP study. The experiment was repeated for everyone with their eyes closed and open. Five different intensities of loudness stimuli (60, 70, 80, 90, 100 dB) were used for the LDAEP study, and the data obtained were selected only for electrodes Fz, Cz, Pz. Comparisons of amplitude means between two different alert states with increasing sound 40 intensity were performed. The amplitudes of the responses with eyes closed are higher than with eyes open is open in all three areas. LDAEP estimates were compared at different vigilance levels. Statistical analysis was performed to assess significance. A positive correlation was obtained between the Cz electrode and the anxiety scale (GAD-7). Thus, it is known that the amplitudes with eyes closed (EC) are higher than with eyes open (EO) in the responses to different intensity sound stimuli. Statistically unreliable results were obtained in LDAEP estimates. However, when eyes are closed (EC) Cz electrode, where LDAEP is most active, we obtained a correlation with GAD-7 anxiety results. From this we can safely say that the priority should be to conduct research with one's eyes closed. |
