| Abstract [eng] |
Analysis of National Biobank and Operating Model Development 70 pages, 21 pictures, 2 charts, 1 annex, 51 references. The main aim of this Master's thesis is to design the Lithuanian Biobank organization's information system operating model based on best international practice. The following tasks have been set to achieve the aim of the work: 1. To analyse scientific literature on the creation of a national biobank; 2. To develop an operational model of a national biobank and it’s organizational structure based on best practices; 3. to detail the national biobank information system according to the main operating processes of a biobank; 4. to develop functional requirements of the main processes of biobank operation. The work consists of three main parts: literature analysis, analysis of main biobank's business processes and business model development, conclusions and recommendations. Literature analysis reviews biobank concept and activities, biobanking activities in Lithuania, information systems used for biobanks, ethical, social, data protection and legal aspects of biobanking, good practices of biobanks "ISBER", biobank organizational structure and processes. Literature analysis is done with the help of analysis and construction methods. It describes the data stored in the biobank IS, created a minimum set of data to be stored and a conceptual data model, the requirements for key business processes and provides business process diagrams, use-case diagrams and functional requirements, and created a biobank IS model. The work was done using drow.io tool, which was used to draw business processes, use-case diagrams, conceptual diagram of biobank IS modules, biobank organization IS activity model and StarUML tool to draw conceptual data model. The Lithuania-adapted biobank information system operating model revealed that the national biobank in Lithuania may be a decentralized model, whereby a new legal entity that independently selects biological samples would be established and its founders would be human biological sample management organizations that have the necessary resources for a successful biobank operation. A nationally developed biobank should have a single information system and a metadata portal integrating different repositories to cover all the services provided by the biobank. For the biobank information system to be in accordance with international best practices, it should have modules for data deidentification, a sample registering and description system and a sample inventory system. The biobank metadata platform would give researchers easy access to biomedical research data and provide appropriate search tools for the biological samples they need. Therefore, the main result of the thesis is an operating model of a biobank information system, which is adapted to Lithuania. Author believes that the operating model of the National Biobank can allow researchers to ensure a better quality of biomedical research, enable modern biomedical research, help develop new treatment and diagnostic tools. |
