Title Neuropsychiatric aspects of Sotos syndrome: explorative review building multidisciplinary bridges in clinical practice /
Authors Lesinskienė, Sigita ; Montvilaitė, Reda ; Pociūtė, Kamilė ; Matulevičienė, Aušra ; Utkus, Algirdas
DOI 10.3390/jcm13082204
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Is Part of Journal of clinical medicine.. Basel : MDPI. 2024, vol. 13, iss. 8, art. no. 2204, p. [1-10].. eISSN 2077-0383
Keywords [eng] Sotos syndrome ; mental health ; child ; adolescent ; personalized treatment ; autism spectrum disorder ; behavioral phenotype ; cognitive profile
Abstract [eng] Background: Sotos syndrome is a genetic disorder caused by NSD1 gene (nuclear receptor binding SET domain containing protein 1) variants and characterized by overgrowth, macrocephaly, learning disabilities, and co-occurring neuropsychiatric symptoms. Methods: Literature sources published in 2002–2023 were selected and analyzed from PubMed and Google Scholar databases. Results: Neuropsychiatric symptoms are observed among children and adolescents with Sotos syndrome. The majority have intellectual disabilities or borderline intellect. Verbal IQ is higher than performance IQ. Individuals display difficulties in expressing language. Aggression is reported by parents. Children express autistic behavior, ADHD, anxiety based on phobias, and early bedtimewake times. Conclusions: Sotos syndrome is associated with neuropsychiatric disorders in children. Slow intellectual and language development, aggressive outbursts, anxiety, autism spectrum disorder, and hyperactivity are present in the newest studies. Comprehensive assistance is needed for Sotos syndrome patients in responding to areas of difficulty. There is still a lack of research on the developmental characteristics of these children and the possibilities of improving psychosocial adaptation by providing multidisciplinary long-term medical, educational, and social care.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2024
CC license CC license description