| Title |
Renal survival and validation of novel international immunoglobulin a nephropathy prediction tool in Latvian population: preliminary data / |
| Authors |
Saulite, Anna Jana ; Popova, Anna ; Erts, Renars ; Racenis, Karlis ; Kucane, Linda ; Petersons, Aivars ; Laurinavičius, Arvydas ; Cernevskis, Harijs ; Kuzema, Viktorija |
| DOI |
10.2478/prolas-2021-0055 |
| Full Text |
|
| Is Part of |
Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences.. Warsaw : Sciendo. 2021, vol. 75, iss. 5, p. 379-386.. ISSN 1407-009X. eISSN 2255-890X |
| Keywords [eng] |
end-stage kidney disease ; immunoglobulin A nephropathy ; kidney survival risk factors ; novel IgAN prediction tool |
| Abstract [eng] |
The aim of the study was to determine kidney survival and validate the novel international immunoglobulin A nephropathy (IgAN) prediction tool (PT) in the Latvian population. Adults with morphologically confirmed IgAN were included. Kidney survival was analysed with the Kaplan-Meier method. PT-assigned risk was compared with calculated risk by the Cox regression model. The Kaplan-Meier analysis included 95 patients. The five-year kidney survival Q3 was 24 months. Women had longer median kidney-survival time (> 60 months) than men (58 months). Median kidney survival in participants with MEST T0 was longer than 60 months; T1 and T2 were 40 and 18 months, respectively. Median kidney survival in participants with diastolic blood pressure (DBP) < 99 mmHg was longer than 60 months, whereas in patients with DBP 100-109 and 110 mmHg, it was 40 and 24 months, respectively. Cox regression analysis included 68 patients. A moderate degree of correlation was found between predicted and observed five-year risk (p = 0.001). Gender, tubular atrophy/interstitial fibrosis, DBP are significant factors affecting kidney survival. Since there was statistically significant correlation and reliability between PT and follow-up analysis data, we conclude that PT could be applied for use in the Latvian population. |
| Published |
Warsaw : Sciendo |
| Type |
Journal article |
| Language |
English |
| Publication date |
2021 |
| CC license |
|
