| Title |
Use of Bacillus subtilis lysate for the immunomodulation of the respiratory system cells / |
| Authors |
Aldonytė, Rūta ; Bironaitė, Daiva ; Bagdonas, Edvardas ; Raudoniūtė, Jovilė ; Konovalovas, Aleksandras ; Danila, Edvardas ; Armalytė, Julija |
| Full Text |
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| Abstract [eng] |
The invention discloses a method and an application of the lysate of Bacillus subtilis for the stimulation of human bronchial epithelium and monocytes in vitro. This invention has direct relevance as an immune stimulator administered against infectious bacterial and non-bacterial diseases when an augmented immune response against an unknown pathogen is required. It works on innate immunity cells, i.e. antigen-presenting monocytederived-macrophages, and within airway epithelium by enhancing barrier functions andpromoting the release of inflammatory mediators. In vitro effects of the lysate involve monocyte differentiation towards macrophages and stimulation of the epithelium to release cytokines and chemokines and tightened intraepithelial junctions. The method proposed here offers an efficient, physiological and affordable way to induce immune stimulation. Such method may be applied in vitro and in clinic since Bacillus subtilis is a ubiquitous bacterium present in water, soil, air, and is considered a beneficial microorganism as it does not possess traits that cause disease. It is not considered pathogenic or toxigenic to humans, animals, or plants. |
| Type |
Patent |
| Language |
English |
| Publication date |
2023 |
