Title Sequelae and post-thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol /
Authors Dam, Merete ; Lynggaard, Line Stensig ; Jónsson, Ólafur G ; Šaulytė Trakymienė, Sonata ; Palk, Katrin ; Jarvis, Kirsten ; Andrés-Jensen, Liv ; Tuckuviene, Ruta ; Albertsen, Birgitte Klug
DOI 10.1002/pbc.30937
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Is Part of Pediatric blood and cancer.. Hoboken : John Wiley and Sons Inc. 2024, vol. 71, iss. 6, art. no. e30937, p. [1-9].. ISSN 1545-5009. eISSN 1545-5017
Abstract [eng] The treatment of acute lymphoblastic leukemia (ALL) is frequently complicated by toxicity, including venous thromboembolism (VTE) affecting roughly 8% of patients. VTE can lead to post-thrombotic syndrome (PTS), a group of signs and symptoms developed as a complication to deep venous thrombosis (DVT), imposing risk of permanent disability and reduced quality of life (QoL). PTS prevalence ranges from 0% to 70%, reflecting very heterogenous cohorts and assessment tools. We aimed to estimate sequelae, including PTS and QoL in children and adults (<45 years old) who had a DVT during ALL treatment. PTS and QoL scores were obtained through use of Villalta and Modified Villalta Scale, PedsQL, and Short Form-36 questionnaires. The cohort comprised 20 children (<18 years) and seven adults (median age: 12.9 years, range: 2–44 years) at the time of DVT diagnosis. In total, 25 ALL survivors underwent PTS examination. The examination took place when survivors were 7–48 years (median age: 20.3 years, median follow-up time 6.8 years). QoL was assessed correlating cases with three matching ALL survivors without VTE. Two adults (15.4%) showed mild or moderate PTS. Eight children (66.7%) were diagnosed with mild PTS, while three cases had collaterals as sole symptoms. Pain or symptoms affecting daily life were reported by 16%. No difference in QoL was found (p =.9). This study underscores the need for comprehensive population-based investigations with validation of PTS instruments in ALL survivors.
Published Hoboken : John Wiley and Sons Inc
Type Journal article
Language English
Publication date 2024
CC license CC license description