| Abstract [eng] |
The dissertation aimed to holistically evaluate the influence of maternal food restriction prior to pregnancy and throughout pregnancy on variation of physical status (biometric, morphological and metabolic indices) of two rat offspring generations at different periods of ontogenesis. Adverse early life events, especially those occurring during the critical stages of growth such as embryonic or foetal periods, have been identified as an important risk factor in a number of chronic diseases. Nutrition is one of the most important factors affecting growth and development. However, there is a lack of studies examining the link between maternal nutrition prior to pregnancy and an overall health status of the child. Growth and physical status of the offspring is strongly influenced by the long-term maternal nutritional ecology that can alleviate the shortages of nutritional perturbations during pregnancy. Besides insufficiently investigated, this phenomenon is rarely analysed during the course of a lifetime, though most metabolic alterations manifest or normalize in the second half of life. So, this experiment examined the influence of maternal food restriction and comprehensive physical status of several rat offspring generations up till spontaneous death. Maternal caloric restriction might result in the alteration in the offspring growth, blood parameters and tissue development towards energy storage. The effect is sex specific and the consequences are more evident in males. |
