| Title |
Resistance exercise effects on hippocampus subfield volumes and biomarkers of neuroplasticity and neuroinflammation in older adults with low and high risk of mild cognitive impairment: a randomized controlled trial / |
| Authors |
Vints, Wouter ; Šeikinaitė, Julija ; Gökçe, Evrim ; Kušleikienė, Simona ; Šarkinaitė, Milda ; Valatkevičienė, Kristina ; Česnaitienė, Vida ; Verbunt, Jeanine ; Levin, Oron ; Masiulis, Nerijus |
| DOI |
10.1007/s11357-024-01110-6 |
| Full Text |
|
| Is Part of |
GeroScience.. Dordrecht : Springer. 2024, vol. 46, iss. 4, p. 3971-3991.. ISSN 2509-2715. eISSN 2509-2723 |
| Keywords [eng] |
cognitive aging ; hippocampus ; inflammation ; myokines ; neurotrophic factor ; resistance exercise |
| Abstract [eng] |
Physical exercise is suggested to promote hippocampal neuroplasticity by increasing circulating neurotrophic and anti-inflammatory factors. Our aim was to explore the interplay between the effect of progressive resistance exercise on blood biomarker levels, hippocampal neurometabolite levels and hippocampal volume in older adults with a low compared to a high risk of mild cognitive impairment (MCI). Seventy apparently healthy male/female older adults (aged 60–85 years old) were randomly allocated to a 12 week lower limb progressive resistance or no intervention, stratified for low (< 26/30) or high (≥ 26/30) Montreal Cognitive Assessment (MoCA) score, indicating MCI risk. Outcome measures were blood levels of insulin-like growth factor-1 (IGF-1), interleukin-6 (IL-6) or kynurenine (KYN); hippocampal total and subfield volumes of the cornu ammonis 1 (CA1) and 4 (CA4), subiculum, presubiculum, and dentate gyrus measured with magnetic resonance imaging (MRI); and hippocampus neurometabolites including total N-acetylaspartate (NAA), myo-inositol (mIns), and total creatine (Cr) measured with proton magnetic resonance spectroscopy (1H-MRS). We evaluated the intervention effect, cognitive status effect, their interaction and the bivariate relationship between exercise-induced changes between the outcome measures. Higher kynurenine levels (p = 0.015) and lower subiculum volumes (p = 0.043) were found in older adults with high MCI risk compared to older adults with low MCI risk. Exercise-induced CA1 volume changes were negatively correlated with hippocampal tNAA/mIns level changes (r = -0.605, p = 0.006). This study provides valuable insight in the multifactorial processes related to resistance training in older adults with low or high MCI risk. |
| Published |
Dordrecht : Springer |
| Type |
Journal article |
| Language |
English |
| Publication date |
2024 |
| CC license |
|
