Title Study of psychiatric disorders and evaluation of their treatment using method of auditory evoked potential P300
Translation of Title Psichikos sutrikimų tyrimas ir jų gydymo įvertinimas klausos sukelto potencialo P300 metodu
Authors Dapšys, Kastytis
Full Text Download
Pages 66
Keywords [eng] Evoked potentials ; antipsychotics ; schizophrenia spectrum disorders ; electroconvulsive therapy
Abstract [eng] Recording and analysis of event-related potentials is safe and harmless method of evaluation of cognition and is suitable to follow the changes of cognitive processes induced by psychoactive drugs or other therapeutic procedures. The main aim of the work was to evaluate the influence of atypical antipsychotics risperidone and quetiapine and such nonpharmacological methods as electroconvulsive therapy and metaglossotherapy on the changes of information processing in the auditory system using event-related potential P300 recording and analysis method. Auditory P300 potential was elicited applying “odd-ball” paradigm and recorded at 3 electrode sites (Fz, Cz, Pz). 4 parameters of P300 potential were measured: N2 latency, P300 latency, P300 amplitude and recognition time of target stimulus. Total number of 85 patients with schizophrenia spectrum disorders and mood disorders were studied. Results of this work showed that the parameters of P300 potential are sensitive indicators of abnormalities of information processing in auditory system in the case of schizophrenia spectrum disorders. More considerable positive influence on the event-related potential P300 had atypical antipsychotic quetiapine and that nonpharmacological methods of treatment of psychiatric disorders are as effective as drug therapy with atypical antipsychotics in remediation of cognitive functions.
Published eLABa – Lithuanian Academic Electronic Library
Type Summaries of Doctoral Thesis
Language English
Publication date 2011