| Abstract [eng] |
Cardiovascular diseases (CVD) are the main cause of death all over the Europe and were the most prevalent disease in Lithuania in 2010. Based on some of the data, MS risk factors have different influence on changes of artery structure and function. MS and its components can influence differently the emergence of cardiovascular diseases and advance of complications in men and women. Furthermore, we tried to estimate the number of separate components constituting MS that can have the most significant influence on functional and structural changes in cardiovascular arteries and increase of the left ventricle myocardial mass index. The particularity of changes in different arterial stiffness indicators in patients with MS has not been determined yet in the literature, as well as prognostic value of MS when initiating early disorders in arterial structure and function and left ventricular hypertrophy. The research showed the following results: in subjects with metabolic syndrome irrespectively their gender and age higher intima-media thickness, femoral-carotid arteries pulse wave velocity and left ventricular myocardial mass index were found. However, higher number of atherosclerotic plaques in carotid artery was found only in females. Risk of cardiovascular disorders in males and females with metabolic syndrome is different. Nor in males, neither in females metabolic syndrome had no direct influence on pulse wave velocity, intima-media thickness, hypertrophy of left ventricle and occurrence of atherosclerotic plaques. Femoral-carotid arteries pulse wave velocity and left ventricular myocardial mass index directly depends on the number of cardiovascular risk factors comprising metabolic syndrome both in males and females. Meanwhile, only in females intima-media thickness is associated with increasing number of risk factors. Metabolic syndrome irrespective of age, increases velocity in central arteries and does not affect peripheral arteries hemodynamic. Pulse wave velocity calculation algorithm depends on gender, age, heart rate, mean blood pressure and waist circumference. |
