Title Effects of combined treatment with sodium dichloroacetate and sodium valproate on the genes in inflammation- and immune-related pathways in T lymphocytes from patients with SARS-CoV-2 infection with pneumonia: sex-related differences /
Authors Stakišaitis, Donatas ; Kapočius, Linas ; Tatarūnas, Vacis ; Gečys, Dovydas ; Mickienė, Auksė ; Tamošuitis, Tomas ; Ugenskienė, Rasa ; Vaitkevičius, Arūnas ; Balnytė, Ingrida ; Lesauskaitė, Vaiva
DOI 10.3390/pharmaceutics16030409
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Is Part of Pharmaceutics.. Basel : MDPI. 2024, vol. 16, iss. 3, art. no. 409, p. [1-25].. eISSN 1999-4923
Keywords [eng] inflammation ; investigational medicine ; SARS-CoV-2 infection ; sex-related differences ; sodium dichloroacetate and sodium valproate combination ; T lymphocytes
Abstract [eng] The study presents data on the anti-inflammatory effects of a combination of sodium dichloroacetate and sodium valproate (DCA–VPA) on the expression of inflammation- and immune response-related genes in T lymphocytes of SARS-CoV-2 patients. The study aimed to assess the effects of DCA–VPA on the genes of cytokine activity, chemokine-mediated signaling, neutrophil chemotaxis, lymphocyte chemotaxis, T-cell chemotaxis, and regulation of T-cell proliferation pathways. The study included 21 patients with SARS-CoV-2 infection and pneumonia: 9 male patients with a mean age of 68.44 ± 15.32 years and 12 female patients with a mean age of 65.42 ± 15.74 years. They were hospitalized between December 2022 and March 2023. At the time of testing, over 90% of sequences analyzed in Lithuania were found to be of the omicron variant of SARS-CoV-2. The T lymphocytes from patients were treated with 5 mmol DCA and 2 mmol VPA for 24 h in vitro. The effect of the DCA–VPA treatment on gene expression in T lymphocytes was analyzed via gene sequencing. The study shows that DCA–VPA has significant anti-inflammatory effects and apparent sex-related differences. The effect is more potent in T cells from male patients with SARS-CoV-2 infection and pneumonia than in females.
Published Basel : MDPI
Type Journal article
Language English
Publication date 2024
CC license CC license description