Title Gyvūnų sklerodermijos modeliai ir jų naudojimo galimybės /
Translation of Title Animal models of scleroderma and their application facilities.
Authors Karpec, Diana ; Leonavičienė, Laima ; Bradūnaitė, Rūta ; Venalis, Algirdas ; Kirdaitė, Gailutė
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Is Part of Laboratorinė medicina.. Lietuvos laboratorinės medicinos draugija, Lietuvos žmogaus genetikos draugija. 2014, 16, 4, p. 187-193.. ISSN 1392-6470
Keywords [eng] systemic sclerosis ; experimental animals ; models of scleroderma
Abstract [eng] Relevant animal models are essential tools to investigate in depth the pathogenesis of systemic sclerosis and search of new therapeutic interventions. Several models of scleroderma are currently available but, unfortunately, none of these reflects all features of the human disease. Some of these models present inflammation followed by fibrosis, whether some others primarily mimic autonomous fibroblast activation. Only few models are available and suitable to study small vessels vasculopathy. Hence, we provide an overview of the most important models of systemic scle rosis. There are bleomycin-,hypochlorous acid-, vinilchloride-, topoisomerase I and complete Freund’s adjuvant-induced systemic sclerosis models, sclerodermatous chronic graft- versus-host mice disease model, with prevailing features of inflammation, autoimmunity and fibrosis. Recently three new inducible animal models have been revealed: reactive oxygen species, angioten sin II- and topoisomerase I and complete Freund’s adjuvant- induced scleroderma models. Trans genic, spontaneous, and knockout gene mice models of scleroderma also widely used. Only some models such as UCD-200 ir UCD-206 chickens model, ar Fra-2 mice model are relevant for investigation of small vascular damage. The choise of experimental model of systemic sclerosis depends on the aim of investigation. Drugs that fulfil evidence level A should be tested in at least two of the animal models mentioned earlier addressing different aspects of the disease. More over, the therapeutic effect should be shown in different organs involved in systemic sclerosis. In this article we discuss about widely used animal models of systemic sclerosis and its application facilities for the search of therapeutic tools.
Published Lietuvos laboratorinės medicinos draugija, Lietuvos žmogaus genetikos draugija
Type Journal article
Language Lithuanian
Publication date 2014