| Title |
Investigation of properties of lipid liquid crystalline drug carriers and their interactions with model cell membranes / |
| Translation of Title |
Lipidų skystakristalių vaistų nešiklių savybių ir jų sąveikų su ląstelių membranų modeliais tyrimas. |
| Authors |
Jankunec, Marija ; Jankunec, Marija |
| Full Text |
|
| Pages |
37 |
| Keywords [eng] |
adsorption ; fusion ; hemolysis ; non-lamellar liquid crystal structures ; self-assembly |
| Abstract [eng] |
The aim of this work was to study structural features of lipid liquid crystalline (LC) drug carriers based on soya phosphatidylcholine (SPC), glycerol dioleate (GDO) and water and their interactions with different surfaces. In this thesis were described lipid SPC/GDO LC phases and dispersed nanoparticles (LCNPs). The phase behaviour was studied at the limited and full hydration conditions. The link between LC structure and the function of drug release was presented. The interactions with different model surfaces were designed. It was found that by changing the ratio of SPC and GDO it is possible to control and vary the sustained release of the encapsulated material. This work revealed that LCNPs of SPC/GDO mixtures have low haemolytic activity, and more likely than others investigated LCNPs fit for an intravenous drug delivery. For the first time were investigated the adsorption properties of these nanoparticles on different modified silica surfaces. By changing the surface properties it is possible to control the adsorption. In vitro studies of LCNPs enable to prognosticate their behaviour in vivo. These results will decide on further use of the studied lipid mixtures as release systems of bioactive materials. It will be easier to programme and construct the drug carrier of desirable properties. |
| Type |
Summaries of doctoral thesis |
| Language |
English |
| Publication date |
2013 |
