Title Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago /
Authors Perrone, Gennaro ; Giuffrida, Mario ; Abu-Zidan, Fikri ; Kruger, Vitor F ; Livrini, Marco ; Petracca, Gabriele Luciano ; Rossi, Giorgio ; Tarasconi, Antonio ; Tian, Brian W. C. A ; Bonati, Elena ; Mentz, Ricardo ; Mazzini, Federico N ; Campana, Juan P ; Gasser, Elisabeth ; Kafka-Ritsch, Reinhold ; Felsenreich, Daniel M ; Dawoud, Christopher ; Riss, Stefan ; Gomes, Carlos Augusto ; Gomes, Felipe Couto ; Gonzaga, Ricardo Alessandro Teixeira ; Canton, Cassio Alfred Brattig ; Pereira, Bruno Monteiro ; Fraga, Gustavo P ; Zem, Leticia Gonçalves ; Cordeiro-Fonseca, Vinicius ; de Mesquita Tauil, Renato ; Atanasov, Boyko ; Belev, Nikolay ; Kovachev, Nikola ; Meléndez, L. Juan José ; Dimova, Ana ; Dimov, Stefan ; Zelić, Zdravko ; Augustin, Goran ; Bogdanić, Branko ; Morić, Trpimir ; Chouillard, Elie ; Bajul, Melinda ; De Simone, Belinda ; Panis, Yves ; Esposito, Francesco ; Notarnicola, Margherita ; Lauka, Lelde ; Fabbri, Anna ; Hentati, Hassen ; Fnaiech, Iskander ; Aurélien, Venara ; Bougard, Marie ; Roulet, Maxime ; Demetrashvili, Zaza ; Pipia, Irakli ; Merabishvili, Giorgi ; Bouliaris, Konstantinos ; Koukoulis, Georgios ; Doudakmanis, Christos ; Xenaki, Sofia ; Chrysos, Emmanuel ; Kokkinakis, Stamatios ; Vassiliu, Panteleimon ; Michalopoulos, Nikolaos ; Margaris, Ioannis ; Kechagias, Aristotelis ; Avgerinos, Konstantinos ; Katunin, Jevgeni ; Lostoridis, Eftychios ; Nagorni, Eleni-Aikaterini ; Pujante, Antonio ; Mulita, Francesk ; Maroulis, Ioannis ; Vailas, Michail ; Marinis, Athanasios ; Siannis, Ioannis ; Bourbouteli, Eirini ; Manatakis, Dimitrios K ; Tasis, Nikolaos ; Acheimastos, Vasileios ; Maria, Sotiropoulou ; Stylianos, Kapiris ; Kuzeridis, Harilaos ; Korkolis, Dimitrios ; Fradelos, Evangelos ; Kavalieratos, George ; Petropoulou, Thalia ; Polydorou, Andreas ; Papacostantinou, Ioannis ; Triantafyllou, Tania ; Kimpizi, Despina ; Theodorou, Dimitrios ; Toutouzas, Konstantinos ; Chamzin, Alexandros ; Frountzas, Maximos ; Schizas, Dimitrios ; Karavokyros, Ioannis ; Syllaios, Athanasios ; Charalabopoulos, Alexandros ; Boura, Maria ; Baili, Efstratia ; Ioannidis, Orestis ; Loutzidou, Lydia ; Anestiadou, Elissavet ; Tsouknidas, Ioannis ; Petrakis, Georgios ; Polenta, Eleni ; Bains, Lovenish ; Gupta, Rahul ; Singh, Sudhir K ; Khanduri, Archana ; Bala, Miklosh ; Kedar, Asaf ; Pisano, Marcello ; Podda, Mauro ; Pisanu, Adolfo ; Martines, Gennaro ; Trigiante, Giuseppe ; Lantone, Giuliano ; Agrusa, Antonino ; Di Buono, Giuseppe ; Buscemi, Salvatore ; Veroux, Massimiliano ; Gioco, Rossella ; Veroux, Gastone ; Oragano, Luigi ; Zonta, Sandro ; Lovisetto, Federico ; Feo, Carlo V ; Pesce, Antonio ; Fabbri, Nicolò ; Lantone, Giulio ; Marino, Fabio ; Perrone, Fabrizio ; Vincenti, Leonardo ; Papagni, Vincenzo ; Picciariello, Arcangelo ; Rossi, Stefano ; Picardi, Biagio ; Del Monte, Simone Rossi ; Visconti, Diego ; Osella, Giulia ; Petruzzelli, Luca ; Pignata, Giusto ; Andreuccetti, Jacopo ; D’Alessio, Rossella ; Buonfantino, Massimo ; Guaitoli, Eleonora ; Spinelli, Stefano ; Sampietro, Gianluca Matteo ; Corbellini, Carlo ; Lorusso, Leonardo ; Frontali, Alice ; Pezzoli, Isabella ; Bonomi, Alessandro ; Chierici, Andrea ; Cotsoglou, Christian ; Manca, Giuseppe ; Delvecchio, Antonella ; Musa, Nicola ; Casati, Massimiliano ; Letizia, Laface ; Abate, Emmanuele ; Ercolani, Giorgio ; D’Acapito, Fabrizio ; Solaini, Leonardo ; Guercioni, Gianluca ; Cicconi, Simone ; Sasia, Diego ; Borghi, Felice ; Giraudo, Giorgio ; Sena, Giuseppe ; Castaldo, Pasquale ; Cardamone, Eugenia ; Portale, Giuseppe ; Zuin, Matteo ; Spolverato, Ylenia ; Esposito, Marialusia ; Isernia, Roberta Maria ; Di Salvo, Maria ; Manunza, Romina ; Esposito, Giuseppe ; Agus, Marcello ; Asti, Emanuele Luigi Giuseppe ; Bernardi, Daniele Tiziano ; Tonucci, Tommaso Panici ; Luppi, Davide ; Casadei, Massimiliano ; Bonilauri, Stefano ; Pezzolla, Angela ; Panebianco, Annunziata ; Laforgia, Rita ; De Luca, Maurizio ; Zese, Monica ; Parini, Dario ; Jovine, Elio ; De Sario, Giuseppina ; Lombardi, Raffaele ; Aprea, Giovanni ; Palomba, Giuseppe ; Capuano, Marianna ; Argenio, Giulio ; Orio, Gianluca ; Armellino, Mariano Fortunato ; Troian, Marina ; Guerra, Martina ; Nagliati, Carlo ; Biloslavo, Alan ; Germani, Paola ; Aizza, Giada ; Monsellato, Igor ; Chahrour, Ali Chaouki ; Anania, Gabriele ; Bombardini, Cristina ; Bagolini, Francesco ; Sganga, Gabriele ; Fransvea, Pietro ; Bianchi, Valentina ; Boati, Paolo ; Ferrara, Francesco ; Palmieri, Francesco ; Cianci, Pasquale ; Gattulli, Domenico ; Restini, Enrico ; Cillara, Nicola ; Cannavera, Alessandro ; Nita, Gabriela Elisa ; Sarnari, Jlenia ; Roscio, Francesco ; Clerici, Federico ; Scandroglio, Ildo ; Berti, Stefano ; Cadeo, Alessandro ; Filippelli, Alice ; Conti, Luigi ; Grassi, Carmine ; Cattaneo, Gaetano Maria ; Pighin, Marina ; Papis, Davide ; Gambino, Giovanni ; Bertino, Vanessa ; Schifano, Domenico ; Prando, Daniela ; Fogato, Luisella ; Cavallo, Fabio ; Ansaloni, Luca ; Picheo, Roberto ; Pontarolo, Nicholas ; Depalma, Norma ; Spampinato, Marcello ; D’Ugo, Stefano ; Lepre, Luca ; Capponi, Michela Giulii ; Campa, Rossella Domenica ; Sarro, Giuliano ; Dinuzzi, Vincenza Paola ; Olmi, Stefano ; Uccelli, Matteo ; Ferrari, Davide ; Inama, Marco ; Moretto, Gianluigi ; Fontana, Michele ; Favi, Francesco ; Picariello, Erika ; Rampini, Alessia ; Barberis, Andrea ; Azzinnaro, Antonio ; Oliva, Alba ; Totaro, Luigi ; Benzoni, Ilaria ; Ranieri, Valerio ; Capolupo, Gabriella Teresa ; Carannante, Filippo ; Caricato, Marco ; Ronconi, Maurizio ; Casiraghi, Silvia ; Casole, Giovanni ; Pantalone, Desire ; Alemanno, Giovanni ; Scheiterle, Maximilian ; Ceresoli, Marco ; Cereda, Marco ; Fumagalli, Chiara ; Zanzi, Federico ; Bolzon, Stefano ; Guerra, Enrico ; Lecchi, Francesca ; Cellerino, Paola ; Ardito, Antonella ; Scaramuzzo, Rosa ; Balla, Andrea ; Lepiane, Pasquale ; Tartaglia, Nicola ; Ambrosi, Antonio ; Pavone, Giovanna ; Palini, Gian Marco ; Veneroni, Simone ; Garulli, Gianluca ; Ricci, Claudio ; Torre, Beatrice ; Russo, Iris Shari ; Rottoli, Matteo ; Tanzanu, Marta ; Belvedere, Angela ; Milone, Marco ; Manigrasso, Michele ; De Palma, Giovanni Domenico ; Piccoli, Micaela ; Pattacini, Gianmaria Casoni ; Magnone, Stefano ; Bertoli, Paolo ; Pisano, Michele ; Massucco, Paolo ; Palisi, Marco ; Luzzi, Andrea-Pierre ; Fleres, Francesco ; Clarizia, Guglielmo ; Spolini, Alessandro ; Kobe, Yoshiro ; Toma, Takayuki ; Shimamura, Fumihiko ; Parker, Robert ; Ranketi, Sinkeet ; Mitei, Mercy ; Svagzdys, Saulius ; Pauzas, Henrikas ; Zilinskas, Justas ; Poškus, Tomas ; Kryžauskas, Marius ; Jakubauskas, Matas ; Zakaria, Andee Dzulkarnaen ; Zakaria, Zaidi ; Wong, Michael Pak-Kai ; Jusoh, Asri Che ; Zakaria, Muhammad Nazreen ; Cruz, Daniel Rios ; Elizalde, Aurea Barbara Rodriguez ; Reynaud, Alejandro Bañon ; Hernandez, Edgard Efren Lozada ; Monroy, Jose maria Victor Palomo ; Hinojosa-Ugarte, Diego ; Quiodettis, Martha ; Du Bois, María Esther ; Latorraca, José ; Major, Piotr ; Pędziwiatr, Michał ; Pisarska-Adamczyk, Magdalena ; Walędziak, Maciej ; Kwiatkowski, Andrzej ; Czyżykowski, Łukasz ; da Costa, Silvia Dantas ; Pereira, Bela ; Ferreira, Ana Rita Oliveira ; Almeida, Filipe ; Rocha, Ricardo ; Carneiro, Carla ; Perez, Diego Pita ; Carvas, João ; Rocha, Catarina ; Ferreira, Cátia ; Marques, Rita ; Fernandes, Urânia ; Leao, Pedro ; Goulart, André ; Pereira, Rita Gonçalves ; Patrocínio, Sara Daniela Direito ; de Mendonça, Nuno Gonçalo Gonçalves ; Manso, Maria Isabel Cerqueira ; Morais, Henrique Manuel Cardoso ; Cardoso, Paulo Sebastião ; Calu, Valentin ; Miron, Adrian ; Toma, Elena Adelina ; Gachabayov, Mahir ; Abdullaev, Abakar ; Litvin, Andrey ; Nechay, Taras ; Tyagunov, Alexander ; Yuldashev, Anvar ; Bradley, Alison ; Wilson, Michael ; Panyko, Arpád ; Látečková, Zuzana ; Lacko, Vladimír ; Lesko, Dusan ; Soltes, Marek ; Radonak, Jozef ; Turrado-Rodriguez, Victor ; Termes-Serra, Roser ; Morales-Sevillano, Xavier ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Brachini, Gioia ; Degiuli, Maurizio ; Sofia, Silvia ; Reddavid, Rossella ; de Manzoni Garberini, Andrea ; Buffone, Angelica ; del Pozo, Eduardo Perea ; Aparicio-Sánchez, Daniel ; Dos Barbeito, Sandra ; Estaire-Gómez, Mercedes ; Vitón-Herrero, Rebeca ; de los Ángeles Gil Olarte-Marquez, M ; Gil-Martínez, José ; Alconchel, Felipe ; Nicolás-López, Tatiana ; Rahy-Martin, Aida Cristina ; Pelloni, María ; Bañolas-Suarez, Raquel ; Mendoza-Moreno, Fernando ; Nisa, Francisca García-Moreno ; Díez-Alonso, Manuel ; Rodas, María Elisa Valle ; Agundez, María Carmona ; Andrés, María Inmaculada Pérez ; Moreira, Claudia Cristina Lopes ; Perez, Aintzane Lizarazu ; Ponce, Iñigo Augusto ; González-Castillo, Ana María ; Membrilla-Fernández, Estela ; Salvans, Silvia ; Serradilla-Martín, Mario ; Pardo, Pablo Sancho ; Rivera-Alonso, Daniel ; Dziakova, Jana ; Huguet, Jose Mugüerza ; Valle, Naila Pagès ; Ruiz, Enrique Colás ; Valcárcel, Cristina Rey ; Moreno, Cristina Ruiz ; Salazar, Yeniffer Tatiana Moreno ; García, Juan Jesús Rubio ; Micó, Silvia Sevila ; López, Joaquín Ruiz ; Farré, Silvia Pérez ; Gomez, Maite Santamaria ; Petit, Nuria Mestres ; Titos-García, Alberto ; Aranda-Narváez, Jose Manuel ; Romacho-López, Laura ; Sánchez-Guillén, Luis ; Aranaz-Ostariz, Veronica ; Bosch-Ramírez, Marina ; Martínez-Pérez, Aleix ; Martínez-López, Elías ; Sebastián-Tomás, Juan Carlos ; Jimenez-Riera, Granada ; Jimenez-Vega, Javier ; Cuellar, Jose Aurelio Navas ; Campos-Serra, Andrea ; Muñoz-Campaña, Anna ; Gràcia-Roman, Raquel ; Alegre, Javier Martínez ; Pinto, Francisca Lima ; O’Sullivan, Sara Nuñez ; Antona, Francisco Blanco ; Jiménez, Beatriz Muñoz ; López-Sánchez, Jaime ; Carmona, Zahira Gómez ; Fernández, Rocio Torres ; Sierra, Isabel Blesa ; de León, Laura Román García ; Moreno, Verónica Polaino ; Iglesias, Eva ; Cumplido, Paola Lora ; Bravo, Altea Arango ; Simó, Ignacio Rey ; Domínguez, Carlota López ; Caamaño, Aloia Guerreiro ; Lozano, Rafael Calleja ; Martínez, Manuel Durán ; Torres, Álvaro Naranjo ; de Quiros, Javier Tomas Morales Bernaldo ; Pellino, Gianluca ; Cloquell, Miriam Moratal ; Moller, Elsa García ; Jalal-Eldin, Sami ; Abdoun, Ahmed K ; Hamid, Hytham K. S ; Lohsiriwat, Varut ; Mongkhonsupphawan, Aitsariya ; Baraket, Oussama ; Ayed, Karim ; Abbassi, Imed ; Ali, Ali Ben ; Ammar, Houssem ; Kchaou, Ali ; Tlili, Ahmed ; Zribi, Imen ; Colak, Elif ; Polat, Suleyman ; Koylu, Zehra Alan ; Guner, Ali ; Usta, Mehmet Arif ; Reis, Murat Emre ; Mantoglu, Baris ; Gonullu, Emre ; Akin, Emrah ; Altintoprak, Fatih ; Bayhan, Zulfu ; Firat, Necattin ; Isik, Arda ; Memis, Ufuk ; Bayrak, Mehmet ; Altıntaş, Yasemin ; Kara, Yasin ; Bozkurt, Mehmet Abdussamet ; Kocataş, Ali ; Das, Koray ; Seker, Ahmet ; Ozer, Nazmi ; Atici, Semra Demirli ; Tuncer, Korhan ; Kaya, Tayfun ; Ozkan, Zeynep ; Ilhan, Onur ; Agackiran, Ibrahim ; Uzunoglu, Mustafa Yener ; Demirbas, Eren ; Altinel, Yuksel ; Meric, Serhat ; Hacım, Nadir Adnan ; Uymaz, Derya Salim ; Omarov, Nail ; Balık, Emre ; Tebala, Giovanni D ; Khalil, Hany ; Rana, Mridul ; Khan, Mansoor ; Florence, Charlotte ; Swaminathan, Christie ; Leo, Cosimo Alex ; Liasis, Lampros ; Watfah, Josef ; Trostchansky, Ivan ; Delgado, Edward ; Pontillo, Marcelo ; Latifi, Rifat ; Coimbra, Raul ; Edwards, Sara ; Lopez, Ana ; Velmahos, George ; Dorken, Ander ; Gebran, Anthony ; Palmer, Amanda ; Oury, Jeffrey ; Bardes, James M ; Seng, Sirivan Suon ; Coffua, Lauren S ; Ratnasekera, Asanthi ; Egodage, Tanya ; Echeverria-Rosario, Karla ; Armento, Isabella ; Napolitano, Lena M ; Sangji, Naveen F ; Hemmila, Mark ; Quick, Jacob A ; Austin, Tyler R ; Hyman, Theodore S ; Curtiss, William ; McClure, Amanda ; Cairl, Nicholas ; Biffl, Walter L ; Truong, Hung P ; Schaffer, Kathryn ; Reames, Summer ; Banchini, Filippo ; Capelli, Patrizio ; Coccolini, Federico ; Sartelli, Massimo ; Bravi, Francesca ; Vallicelli, Carlo ; Agnoletti, Vanni ; Baiocchi, Gian Luca ; Catena, Fausto
DOI 10.1186/s13017-024-00543-w
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Is Part of World journal of emergency surgery.. London : BioMed Central Ltd. 2024, vol. 19, iss. 1, art. no. 14, p. [1-16].. eISSN 1749-7922
Keywords [eng] colon ; colorectal cancer ; diverticulitis ; emergency surgery ; Hartmann’s procedure ; left side ; ostomy ; primary anastomosis ; resection
Abstract [eng] Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann’s procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment’s choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception.
Published London : BioMed Central Ltd
Type Journal article
Language English
Publication date 2024
CC license CC license description