Title The research of risk factors for local progression of malignant hepatic tumours treated with radiofrequency ablation /
Translation of Title Piktybinių navikų, esančių kepenyse, vietinio progresavimo rizikos veiksnių tyrimas taikant radijo dažnio abliaciją.
Authors Trakymas, Mantas
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Pages 36
Keywords [eng] radiofrequency ablation ; hepatic tumours ; local tumour progression ; risk factors
Abstract [eng] Local tumour progression remains the main problem after radiofrequency ablation of liver tumours and it is usually the only measure of treatment efficacy. The aim of our study was to investigate and evaluate the prognostic value of computed tomography and ultrasonography as well as the histological result of core biopsy material from ablated tumour on assessment of radiofrequency ablation effectiveness. Materials and methods: We have studied 68 malignant primary and metastatic hepatic tumours treated by radiofrequency ablation. Ablation was performed using perfusion electrodes. Evaluation of tumours before ablation and follow up was performed by means of contrast enhanced computed tomography and ultrasonography. Ablation zone was biopsied for histological examination. Results and conclusions: 58 successfully treated hepatic tumours were suitable for the final analysis. The local progression of nine (15.5 %) tumours was detected on follow up. Mean follow up time for analysed tumours was 16.3 months with a range from 1.7 to 38.7 months. It was showed, that: 1. The result of histological examination of ablation zone biopsy material taken one month after radiofrequency ablation of malignant liver tumour does not predict local tumour progression. 2. Tumour size 30 mm and larger and tumour proximity closer than 5 mm to hepatic vessels larger than 3 mm are significant risk factors for local tumour progression after radiofrequency ablation of malignant liver tumours 3. Tumour type, tumour density and enhancement pattern by computed tomography and tumour echogenicity are not the risk factors for local tumour progression.
Type Summaries of doctoral thesis
Language English
Publication date 2009