| Abstract [eng] |
Women were treated with postoperative radiotherapy by using the gamma-neutrons’ source for treatment of endometrial cancer within the period from October 1, 1996 till March 1, 1998 at the Institute of Oncology of Vilnius University were surveyed in this study. Objective: to estimate the efficiency of endometrial cancer postoperative radiotherapy treatment by using the gamma-neutron source. Goals :1) to estimate one, two, three and five - year survival in a group of patients; 2) to estimate one, two, three and five - year survival according to the patients’ age; 3) to estimate one, two, three and five - year survival according to the tumor characteristics: morphologic tumor type, tumor differentiation degree; 4) to estimate one, two, three and five - year survival according to the radiotherapy characteristics: radiotherapy type, radiotherapy duration. Materials and Methods: The used materials consist of the case records collected at the Institute of Oncology of Vilnius University as well as of the data of the Cancer Register - overall 64 patients’ case records: 52 patients have had combined postoperative radiotherapy and 12 have had vaginal brachytherapy. The data were analyzed by the SPSS statistical package (Version 11.0 for Windows). The statistical assessment and analysis were performed with the qui-square (χ2), Kruscal-Wallis H test with values of p < 0,05 being defined as significant. The survival analysis was performed by using the Kaplan - Meier and life tables’ method. To estimate the difference between the respective groups in the survival analysis, the log rank test was used. Results: The vaginal brachytherapy + distance gamatherapy patients’ survival mean was 110 months (9,2 years), and for vaginal brachytherapy group patients - 92 months (7,7 years). The survival time in months varied from the minimal two to the maximum 142 months (11,8 years). Till the completion of the observation time (November 1, 2007), 62,5 percent of the patients survived. One, two, three and five-year survival rates for patients with vaginal brachytherapy was 75 percent., and for patients with vaginal brachytherapy + distance gamatherapy: 96,2 percent, 90,4 percent, 86,5 percent, 80,8 percent. There was no statistically significant difference observed depending on the age of the patients and their survival (p>0,05). For the I stage 1, 2, 3 and five years survival was better than for the II stage, and the III stage survival was the worst, statistically significant difference was obtained (χ2 = 8,93, df=2, p=0,0115, log rank tests). Between the histology tumor type and survival, there was no statistically significant difference obtained (p>0,05). Between the G1, G2 and G3 tumor differentiation degree and survival, there was no statistically significant difference obtained (p>0,05). Between different total dozes and one, two, three and five-year survival, no statistically significant difference was obtained (p>0,05). Conclusions: The efficiency of postoperative treatment by using gamma-neutrons' source to endometrial cancer’s treatment was efficient, but depended on individual characteristics of a patient and tumor. Key words: : endometrium cancer, brachytherapy, 252Cf. |
