| Title |
Optinis neuritas sergant mielino oligodendrocito glikoproteinų antikūnų asocijuota liga: klinikinis atvejis / |
| Translation of Title |
Optic neuritis caused by myelin oligodendrocyte glycoprotein antibody-associated disease: clinical case report. |
| Authors |
Tilindytė-Muliuolienė, Emilė ; Samaitienė-Aleknienė, Rūta |
| DOI |
10.53453/ms.2024.5.18 |
| Full Text |
|
| Is Part of |
Medicinos mokslai = Journal of medical science.. Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras. 2024, vol. 12, iss. 3, p. 165-177.. eISSN 2345-0592 |
| Keywords [eng] |
autoimmune encephalomyelitis ; optic neuritis ; anti-MOG associated encephalomyelitis ; MOG-IgG test ; demyelinating disease of the central nervous system. |
| Abstract [eng] |
Background. Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatoryautoimmune disorder of the central nervous system (CNS) that has been identified and actively researched in the last decade. It is characterized by episodes of immune-mediated demyelination of the brain, spinal cord, and optic nerves. The recognition of MOGAD significantly changed the approach to the diagnosis and treatment of demyelinating diseases of the central nervous system (CNS) and optic neuritis (ON). Case report. This article describes the case of an 11-year-old patient with ON caused by MOG antibodies. The diagnosis of MOGAD was confirmed based on clinical history, head and neck magnetic resonance imaging (MRI), and serological tests. For the first time the disease manifested as acute disseminated encephalomyelitis (ADEM), similar symptoms were observed during the first relapse. MOGAL optic neuritis occurred during the second relapse, two more relapses manifested later, both of them as ON. Disease relapses were treated with methylprednisolone initial pulse-therapy and prednisolone tapering. Maintenance treatment was continued with intravenous immunoglobulin, mycophenolate mofetil and rituximab. Although the effect of treatment was positive and regression of symptoms was observed, the course of the disease remained relapsing. Conclusion. ON is one of the most common manifestations of MOGAD, and is characterized by relapses and cumulative visual impairment, therefore, when differentiating the causes of ON, it is important to test for MOG antibodies, as the tactics of supportive treatment may depend on it. |
| Published |
Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2024 |
| CC license |
|
