Title Prognostic significance of soluble PD-L1 in prostate cancer /
Authors Žvirblė, Margarita ; Survila, Žilvinas ; Bosas, Paulius ; Dobrovolskienė, Neringa ; Mlynska, Agata ; Zaleskis, Gintaras ; Juršėnaitė, Jurgita ; Characiejus, Dainius ; Pašukonienė, Vita
DOI 10.3389/fimmu.2024.1401097
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Is Part of Frontiers in immunology.. Lausanne : Frontiers Media SA. 2024, vol. 15, art. no. 1401097, p. 1-14.. ISSN 1664-3224. eISSN 1664-3224
Keywords [eng] prostate cancer ; soluble PD-L1 and PD-1 ; biomarkers ; prognosis prediction ; immune cells
Abstract [eng] Purpose: The aim of this study was to assess the role of sPD-L1 and sPD-1 as potential biomarkers in prostate cancer (PCa). The association of the values of these soluble proteins were correlated to the clinical data: stage of disease, Gleason score, biochemical recurrence etc. For a comprehensive study, the relationship between sPD-L1 and sPD-1 and circulating immune cells was further investigated. Methods: A total of 88 patients with pT2 and pT3 PCa diagnosis and 41 heathy men were enrolled. Soluble sPD-L1 and sPD-1 levels were measured in plasma by ELISA method. Immunophenotyping was performed by flow cytometry analysis. Results: Our study’s findings demonstrate that PCa patients had higher levels of circulating sPD-L1 and sPD-1 comparing to healthy controls (p < 0.001). We found a statistically significant (p < 0.05) relationship between improved progression free survival and lower initial sPD-L1 values. Furthermore, patients with a lower sPD-1/sPD-L1 ratio were associated with a higher probability of disease progression (p < 0.05). Additionally, a significant (p < 0.05) association was discovered between higher Gleason scores and elevated preoperative sPD-L1 levels and between sPD-1 and advanced stage of disease (p < 0.05). A strong correlation (p < 0.05), between immunosuppressive CD4+CD25+FoxP3+ regulatory T cells and baseline sPD-L1 was observed in patients with unfavorable postoperative course of the disease, supporting the idea that these elements influence each other in cancer progression. In addition to the postoperative drop in circulating PD-L1, the inverse relationship (p < 0.05), between the percentage of M-MDSC and sPD-L1 in patients with BCR suggests that M-MDSC is not a source of sPD-L1 in PCa patients. Conclusion: Our findings suggest the potential of sPD-L1 as a promising prognostic marker in prostate cancer.
Published Lausanne : Frontiers Media SA
Type Journal article
Language English
Publication date 2024
CC license CC license description