| Title |
Imunosupresines, citotoksines bei imunomoduliuojančias savybes atspindinčių žymenų raiška imunogeniškomis vėžio formomis sergančių pacientų periferinio kraujo CD8h T limfocitų populiacijoje / |
| Translation of Title |
Expression of biomarkers, representing immunosuppressive, cytotoxic or immunomodulating properties of Cd8h T lymphocytes in the peripheral blood of patients with immunogenic cancer forms. |
| Authors |
Strioga, Marius |
| Full Text |
|
| Pages |
124 |
| Keywords [eng] |
CD8hCD57+ T-cell subsets ; individualized antitumor immunotherapy ; renal cell carcinoma ; cutaneous melanoma |
| Abstract [eng] |
The aim of the study was to evaluate the expression of immunosuppressive (FOXP3, NKG2A), and cytotoxic (perforin) or cytotoxic / immunomodulating (IFNγ) T-cell properties representing biomarkers in the peripheral blood CD8h T-cell population of patients with advanced renal cell carcinoma (RCC) or high risk cutaneous melanoma and healthy controls by multicolour flow cytometry. Determination of the percentage of functionally competing T-cell subsets (especially immunosuppressive) in the CD8hCD57+ T-cell subpopulation in future may serve as one of parameters enabling to assess the overall status of antitumor immune response and select cancer patients most suitable for antitumor immunotherapy while dismissing those to whom it would be ineffective or even harmful. |
| Type |
Doctoral thesis |
| Language |
Lithuanian |
| Publication date |
2010 |
