| Abstract [eng] |
The same immunological and inflammatory pathophysiological factors are involved in the mechanism of bone turnover and in atherosclerosis which is closely related to a change in glucose and cholesterol metabolism, obesity and blood pressure problems. The results of studies on the relationships between bone turnover, bone mineral density and serum lipids and the components of metabolic syndrome are inconclusive. The aim of this study was to investigate and evaluate the association of characteristics of bone turnover and structure with serum lipids and metabolic syndrome components. We examined 241 male and 300 female. Was found that bone turnover markers – serum C-terminal cross-linking telopeptide of type I collagen (s-CTX-I) and procollagen type I N propeptide (PINP) – were negatively correlated with the level of triglycerides. It was found that in women with T-score between -1 and -2.5, spine bone mineral density correlated with triglycerides and negatively correlated with high-density lipoprotein cholesterol. In men with T-score -2.5 and lower, femoral neck bone mineral density correlated with total cholesterol and triglycerides. In both genders, the bone mineral density statistically significantly depended with the bone resorption marker s-CTX-I, waist circumference and age. In metabolic syndrome, there are also other factors affecting bone mineral density: low density lipoprotein cholesterol and triglycerides. |
