| Title |
Šlapimo pūslės vėžio diagnostikos rezultatų palyginimas audinių virpesinės spektroskopijos, citologijos ir histologijos metodais / |
| Translation of Title |
Comparison of bladder cancer diagnostic results by tissue vibrational spectroscopy, cytology, and histology methods. |
| Authors |
Platkevičius, Gediminas |
| DOI |
10.15388/vu.thesis.638 |
| Full Text |
|
| Pages |
136 |
| Keywords [eng] |
Bladder cancer ; spectroscopy ; SERS ; IR spectroscopy |
| Abstract [eng] |
The current literature focuses on non-invasive diagnosis of oncological diseases. Vibrational spectroscopy techniques are characterized by the ability to distinguish between substances based on their molecular differences without damaging the substances (or tissues). In this study, two vibrational spectroscopy methods were used to differentiate between bladder cancer and non-cancerous tissue under ex vivo conditions: surface-enhanced Raman scattering spectroscopy (SERS) and fiber-based attenuated total reflection infrared spectroscopy (IR spectroscopy). The first method (SERS) was used to study bladder cancerous and non-cancerous tissue samples, their interstitial fluid samples, and bladder washings from bladder cancer and healthy patients. The second method (IR spectroscopy) was used to analyze cancerous and non-cancerous tissue samples. The main spectral differences under ex vivo conditions were found to distinguish between non-cancerous and cancerous tissues in the SERS spectra of interstitial fluid samples and in the IR spectra of bladder tissue samples. Differences in spectral bands were also found between bladder washings from healthy and bladder cancer patients. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Doctoral thesis |
| Language |
Lithuanian |
| Publication date |
2024 |
