Title A general biochemical kinetics data fitting algorithm for quasi-steady-state detection
Translation of Title Apibendrintas biocheminės kinetikos duomenų analizės algoritmas kvazi-stacionarių būsenų aptikimui.
Authors Daugmaudis, Justinas Vygintas ; Laurynėnas, Audrius ; Kulys, Juozas ; Ivanauskas, Feliksas
DOI 10.15388/LMR.A.2016.03
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Is Part of Lietuvos matematikos rinkinys. Proceedings of the Lithuanian Mathematical Society. Ser. A.. Vilnius : Vilniaus Universitetas. Matematikos ir Informatikos Insititutas. 2016, t. 57, p. 12-17.. ISSN 0132-2818. eISSN 2335-898X
Keywords [eng] biochemical kinetics ; differential equations ; curve fitting ; reaction rate constants ; phosphatase ; 4-nitrophenylphosphate
Abstract [eng] We develop a general algorithm for fitting the biochemical kinetics data. The developed algorithm searches and analyzes numerous minima. This approach allows us to analyze biochemical data without a priori quasi-steady-state assumptions. The algorithm allows us to treat the biochemical kinetics data that has varying degree of steadiness. We test the approach by analyzing experiment data from 4-nitrophenyl phosphate hydrolysis with alkaline phosphatase.
Published Vilnius : Vilniaus Universitetas. Matematikos ir Informatikos Insititutas
Type Journal article
Language English
Publication date 2016
CC license CC license description