| Abstract [eng] |
ANA JURĖNIENĖ Genetic Variability and Mutation Rate of Human Y Chromosome in Lithuanian Population SUMMARY . The goal of this master's work was to investigate Y chromosomal study, using 17 Y STR system: DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385a, DYS385b, DYS393, DYS391, DYS439, DYS635, DYS392, Y_GATA_H4, DYS437, DYS438, DYS448 in Lithuanian population. Multiple haplotypes where identified for every analyzed person after genotyping Lithuanian citizens Y chromosome bye research regions. During research where identified 129 different Y chromosome multiple haplotypes. Mutations rate was identified by researching 126 pairs of Y chromosome father-son (confirmed by autosomal STR analysis) of Lithuanian population. During the investigation studies following result was obtained: low Y chromosome’s 17 Y-STR’s regions allele polymorphism level and low mutations rate. Y-STR’s region allele rates show, that Lithuanian males population is homogenous and genetically not decomposed population. Increasing number of microsatelites will get possibilities to found more variability of haplotypes inside and between populations. |
