CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival /

Camille Danne; Chloé Michaudel; Jūratė Skerniškytė; Julien Planchais; Aurélie Magniez; Allison Agus; Marie-Laure Michel; Bruno Lamas; Gregory Da Costa; Madeleine Spatz; Cyriane Oeuvray; Chloé Galbert; Maxime Poirier; Yazhou Wang; Alexia Lapière; Nathalie Rolhion; Tatiana Ledent; Cédric Pionneau; Solenne Chardonnet; Floriant Bellvert; Edern Cahoreau; Amandine Rocher; Rafael Rose Arguello; Carole Peyssonnaux; Sabine Louis; Mathias L Richard; Philippe Langella; Jamel El-Benna; Benoit Marteyn; Harry Sokol

doi:10.1136/gutjnl-2022-326917

Title	CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival /
Authors	Danne, Camille ; Michaudel, Chloé ; Skerniškytė, Jūratė ; Planchais, Julien ; Magniez, Aurélie ; Agus, Allison ; Michel, Marie-Laure ; Lamas, Bruno ; Da Costa, Gregory ; Spatz, Madeleine ; Oeuvray, Cyriane ; Galbert, Chloé ; Poirier, Maxime ; Wang, Yazhou ; Lapière, Alexia ; Rolhion, Nathalie ; Ledent, Tatiana ; Pionneau, Cédric ; Chardonnet, Solenne ; Bellvert, Floriant ; Cahoreau, Edern ; Rocher, Amandine ; Arguello, Rafael Rose ; Peyssonnaux, Carole ; Louis, Sabine ; Richard, Mathias L ; Langella, Philippe ; El-Benna, Jamel ; Marteyn, Benoit ; Sokol, Harry
DOI	10.1136/gutjnl-2022-326917
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Is Part of	Gut.. London : BMJ Publishing Group. 2023, vol. 72, iss. 6, p. 1081-1092.. ISSN 0017-5749. eISSN 1468-3288
Keywords [eng]	apoptosis ; gastrointestinal immune response ; gut inflammation ; IBD ; IBD - genetics
Abstract [eng]	Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to alterations in the gastrointestinal immune response and chronic inflammation. Caspase recruitment domain 9 ( Card9 ), one of the IBD susceptibility genes, has been shown to protect against intestinal inflammation and fungal infection. However, the cell types and mechanisms involved in the CARD9 protective role against inflammation remain unknown.
Published	London : BMJ Publishing Group
Type	Journal article
Language	English
Publication date	2023
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„CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival /“