| Abstract [eng] |
The study provides scientifically based information about the oncological safety of active surveillance of small kidney tumors. It identifies the prognostic factors of aggressive kidney cancer that can help the urologist choose the right treatment tactics.The work evaluated the predictive value of epigenetic markers in determining aggressive forms of kidney cancer and predicting rapid tumor growth.To our knowledge, this study is the first to analyze DNA methylation in urine samples from patients with small renal tumors and demonstrates its potential as a non-invasive tool for the detection of small (up to 4 cm in diameter) malignancies. According to our available data, studies that evaluated the influence of clinical data such as obesity, smoking, elevated arterial blood pressure, metabolic syndrome, dyslipidemia, or the psychoemotional state of the patient on the progression of small, observed kidney tumors, i.e. for rapid tumor growth, have not been performed so far. Based on the fact that Lithuania has one of the highest rates of incidence and mortality of kidney cancer in Europe, it is necessary to evaluate the effectiveness of systemic treatment in patients with advanced kidney cancer. |
