| Abstract [eng] |
There is conflicting evidence as to whether vitamin D deficiency contributes to physical performance and muscle mass. Many studies have shown that the heritability of bone mineral density and other determinants of low-trauma bone fracture risk, but there is lack of data on specific genetic polymorphism effect. The aim of this study was to investigate association between vitamin D, bone mineral density, muscle mass, physical performance, falls and and evaluate VDR gene molecular and genetic polymorphism in the elderly. We examined 392 aged 60 years and older persons. Serum 25-hydroxyvitamin D (25(OH)D) was measured by fully automated electrochemical luminescence immunoassay method. Bone mineral density, muscle mass was investigated using dual energy x-ray absorptiometry. Vitamin D receptor gene was determined using polymerase chain reaction analysis with specially designed primers. Vitamin D deficiency was found in most of the investigated people: 72.2 % of women and 65.6 % of men. Lowest vitamin D levels were found in men and women aged 80 years and older. Vitamin D statistically significantly positively associated with the handgrip strength in women and muscle mass in men, as well as with bone mineral density in both genders. Low muscle mass, low handgrip strength, and low gait speed was significantly associated with falls in the elderly. In women with severe postmenopausal osteoporosis, the lumbar spine BMD was significantly higher in the VDR BsmI gene BB genotype bearers comparing to the bb and Bb genotype bearers. |
