| Abstract [eng] |
To this day, thyroid cancer is the most common malignancy of the endocrine system, and about 30% consists of papillary thyroid microcarcinoma. The main treatment for thyroid cancer remains surgery. However, for patients who experience psychological stress after suggested monitoring of the disease, and for those who are unwilling to undergo open surgery or are at high surgical risk, minimally invasive treatments such as laser ablation were proposed. The study aims to study the laser effect on thyroid tissue and to identify the optimal laser parameters for the size of the coagulated zone to meet the recommended diameter for the treatment of papillary thyroid microcarcinoma. Seventy-two swine thyroid glands were used in this study for laser ablation. Leonardo Dual and Leonardo Mini Dual lasers were used, emitting wavelengths of 1064 nm and 980 nm, respectively. Twelve different power and energy combinations were applied: power of 3W, 5W, and 7W, and energy of 750J, 1000J, 1250J, and 1500J. Measurements and ablation evaluations were conducted through gross and histopathological analysis. In total, 69 out of 72 thyroid glands were appropriate for the study. In most samples, no coagulation zone was observed with the use of a 1064 nm wavelength. In this group of samples, not one coagulated area reached 10 mm in diameter with recommended 2 mm margins, in total 14 mm in diameter. All samples in group of a wavelength of 980 nm had visible coagulation zones. For the largest papillary thyroid microcarcinoma, the optimal laser settings were a wavelength of 980 nm, power of 5W, and energy of 1250J, achieving an average diameter of 14.67±2.52 mm. |
