Title Gut microbiome impact on postoperative morbidity after major abdominal oncological surgery /
Translation of Title Žarnų mikrobiomos reikšmė pooperacinių komplikacijų vystymesi po didžiųjų pilvo organų operacijų dėl onkologinių susirgimų.
Authors Kurlinkutė, Agnė
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Pages 22
Keywords [eng] Raktažodžiai: žarnyno mikrobiota, operaciniai rezultatai, virškinamojo trakto vėžys, Bacteroides fragilis, interleukinas-17, trumposios grandies riebalų rūgštys, žarnyno uždegimas. Keywords: intestinal microbiome, surgical outcomes, gastrointestinal cancer, Bacteroides fragilis, interleukin-17, short-chain fatty acid production, intestinal inflammation.
Abstract [eng] Approximately one third of gastrointestinal cancer patients experience post-operative complications. In today's literature, the microbiome is acknowledged as a potential contributor to the pathogenesis of post-operative complications. However, the exact role is not clear. Consequently, this comprehensive review was conducted to summarize existing data on the possible role of intestinal microbiome in the pathogenesis of postoperative complications. A literature search was conducted using the PubMed database, selecting human studies that investigated the link between intestinal microbiome and short-term outcomes of gastrointestinal cancer surgery. After the search, five studies published between 2018 and 2023 were included. All studies addressed the complication of anastomotic leakage, with four studies focusing on anastomotic leakage following colorectal cancer surgery and one study examining anastomotic leakage after esophagectomy. Bacteroides fragilis and Ruminococcus torques were identified as prevalent bacteria in patients with anastomotic leakage in two studies, suggesting a potential role in increasing the risk of this complication. Further discussion revealed that some of the bacterial species, related to increased rates of anastomotic leakage, induced interleukin-17 production. The possibility of a link between anastomotic leakage and interleukin-17 is supported by the interleukin-17 induced upregulated activity of matrix metalloproteinases, which degrade collagen. Bacterial species thought to promote intestinal healing were found to be potentially beneficial through the production of short-chain fatty acids and the reduction of intestinal inflammation, primarily via induced production of interleukin-10.
Dissertation Institution Vilniaus universitetas.
Type Master thesis
Language English
Publication date 2024