| Abstract [eng] |
This systematic review aimed to evaluate the effectiveness of autologous platelet concentrates (APCs) compared to traditional blood-clot regeneration for the management of permanent necrotic teeth. The literature published between 2000 and 2024 was searched in the digital databases of PubMed, Web of Science, Science Direct, and Google Scholar. The search revealed 23 eligible articles, which were included in the study. In total, seven Randomized control trials, one prospective randomized trial, one retrospective controlled cohort study, and fourteen clinical studies were analyzed. The outcomes at postoperative follow-up, such as dentinal wall thickness (DWT), increase in root length (RL), apical closure (AC), vitality response, and success rate, were included in the analysis. The results showed that autologous platelet concentrates significantly improved apical closure and response to vitality pulp tests, whereas no significant effect was observed on root lengthening, dentin wall thickness, or success rate of permanent necrotic teeth treated with regenerative endodontics. Autologous platelet concentrates could be beneficial when treating permanent necrotic teeth for better apical closure and may improve response to vitality tests. Regenerative endodontic procedures (REPs) can be used to treat immature necrotic teeth with stem cell-containing scaffolds. However, challenges like scaffold formation uncertainty and crown discoloration persist. Autologous platelet concentrates show promise in addressing these challenges, with slightly improved success rates. Further clinical trials and standardization of the research are crucial to give evidence-based recommendations for clinicians and to advance the field of regenerative endodontics. |
