| Abstract [eng] |
INTRODUCTION: Arterial hypertension management is a major challenge to the healthcare system as despite developed drug therapies there are many cases of uncontrolled arterial hypertension. Novel interventional therapies are being researched which modify the sympathetic nervous system. RESULTS: Baroreflex activation therapy and endovascular baroreflex amplification are targeting baroreflex by enhancing the activity of baroreceptors. Clinical trials show the effectiveness of these treatment methods, however further randomised trials are necessary. Renal artery denervation is targeting the nerves near the adventitial layer of the renal arteries and causes reduction in the nerve activity. This procedure is proved to be effective and safe by several randomised clinical trials and is approved as a treatment option in patients with drug resistant arterial hypertension. Carotid body resection and ablation are targeting chemoreflex by eliminating chemoreceptor cells in a carotid body. First clinical trials researching these interventional procedures did not prove their effectiveness in treating arterial hypertension. CONCLUSIONS: Baroreflex activation therapy, endovascular baroreflex amplification and renal artery denervation are considered as effective treatment methods of arterial hypertension. Before any of these new technologies can be integrated as a standard of arterial hypertension management, there is a need of an efficacy and safety data from longterm randomized controlled trials. |
