Title Integruota prostatos mpMRT vizualizuojamų židinių analizė: ADC ir kontrastavimosi pobūdžio reikšmė /
Translation of Title Integrated analysis of focal lesions in prostate mpmri: insights from adc and contrast enhancement patterns.
Authors Trakymas, Gaudas Benediktas
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Pages 20
Abstract [eng] Author: Gaudas Benediktas Trakymas. Scientific supervisor: dr. Rūta Briedienė. Title: Integrated Analysis of Focal Lesions in Prostate mpMRI: Insights from ADC and Contrast Enhancement patterns. Aim. To analyze and determine the impact of contrast enhancement on the radiological prediction of histologically confirmed malignancy of prostate lesions based on the PI-RADS v2.1 score. Methods. This study was conducted retrospectively by analyzing prostate MRI images and their histological biopsy results from patients included in a biomedical study at the National Cancer Institute of Lithuania during 2021-2022. The reviewed data set included lesions evaluated with PI-RADS v2.1 scores of 3 and 4. All lesions were assessed using multiparametric MRI. All reviewed data was anomymous. Biopsies were performed using ultrasound and MRI fusion technology with the BIOJET system. Results. During the study, 332 prostate lesions rated as PI-RADS v2.1 3 and 4 were analyzed. Out of these, 189 lesions (57%) were histologically confirmed as prostate cancer. Clinically significant cancer (≥GG2) was found in 66 lesions (20%). The highest proportion of clinically significant cancer was observed among lesions rated as PI-RADS 4 with early contrast uptake in dynamic contrast enhancement (DCE). Conclusions. In multiparametric MRI, finding a pathological lesion in the peripheral zone of the prostate without significant diffusion restriction usually does not increase the likelihood of clinically significant cancer. However, significant diffusion restriction in the peripheral zone coupled with early contrast enhancement indicates a high probability of clinically significant prostate cancer.
Dissertation Institution Vilniaus universitetas.
Type Master thesis
Language Lithuanian
Publication date 2024