| Abstract [eng] |
Research relevance: Diabetes mellitus and breast cancer are two heterogeneous, polyetiological, severe chronic diseases. Both are common in today's ageing population and their association can have important implications for health and quality of life. Epidemiological studies show that diabetes increases the risk of liver, breast, colorectal and uterine cancers, and that such patients may have poorer survival. The aim of the research: To assess the impact of diabetes on survival in breast cancer patients. Research tasks: 1. To assess the impact of diabetes on survival in women with breast cancer (i.e. to compare the survival of women with and without CD, both overall, by age and stage of disease). 2. To evaluate 5-year survival rates in breast cancer. 3. To evaluate long-term survival rates in breast cancer. Methodology: Data from the Lithuanian Cancer Institute were used for survival analysis. To assess the impact of diabetes on 5-year survival of breast cancer patients, differences in survival rates were evaluated according to demographics at diagnosis (stage of disease, age). Results were processed using Microsoft Office Excel 2019 and IBM SPSS Statistic 28.0. The Kaplan-Meier method was used for survival analysis and the log-rank test was used to compare the data. The significance level for testing statistical hypotheses was set at p<0.05. Results and conclusions: Diabetes affects survival in breast cancer patients. At 5 years, women with breast cancer but without CD had a higher survival probability than women with both diseases (41.01% and 35.07%, respectively). The older the age of the woman with breast cancer and CD, the lower the survival probability. The most pronounced prognosis is seen in the age group 60 to 69 years, as the 5-year survival probability for women with CD was only 36% and for those without CD 43.20%. When comparing the 5-year survival rates of CD patients and non-CD patients by breast cancer stage, the differences are more pronounced in stage I and II breast cancer. Women with CD and stage I breast cancer have a significantly lower survival probability (49.50%) than women without CD (69.60%). Women with stage II breast cancer and CD also had a lower survival probability (34.30%) than women without CD (48%). Key words: Diabetes mellitus, Breast cancer, Diabetes mellitus and breast cancer. |
