Title Dupuytren᾿s disease: ethiopathogenesis, clinical manifestation, types of surgery, surgery vs conservative treatment – literature review /
Translation of Title Dupuytren᾿s Disease: Ethiopathogenesis, Clinical Manifestation, Types of Surgery, Surgery Vs Conservative Treatment – Literature Review.
Authors Hartmann, Jakob
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Pages 32
Keywords [eng] Dupuytren’s Disease, Dupuytren’s Contracture, Morbus Dupuytren, surgical treatment, conservative treatment, pathophysiology, genetic factors, collagenase injections, radiotherapy, physical therapy, treatment outcome, patient satisfaction
Abstract [eng] This literature review discusses Dupuytren’s Disease, a fibroproliferative disorder characterized by progressive fibrosis of the palmar fascia leading to contracture of the fingers, mainly affecting the ring and little fingers. The context of this review is the significant impact of Dupuytren’s Disease on hand function and quality of life in patients, as well as the challenges it poses in clinical management due to its complex aetiology and variable progression. The aim is to summarize the current knowledge of Dupuytren’s Disease with a focus on its pathogenesis, treatment efficacy, and patient outcomes, with the intention of illuminating areas for further research and potential improvement in patient care. Methodologically, the review pools and critically appraises studies from different databases, adhering to inclusion criteria to ensure relevance and rigor. These criteria include studies on genetic determinants of Dupuytren’s Disease, cellular mechanisms, and treatment outcomes, as well as both surgical and conservative approaches. Findings reveal a multifactorial aetiology involving genetic predisposition and environmental factors, with treatments ranging from invasive surgical options to non-invasive modalities that show varying efficacy in different patient groups. Surgical interventions, although effective for the present, carry a risk of recurrence and complications, whereas conservative treatments offer safer, although sometimes less durable, results. The importance of this work lies in the comprehensive review of Dupuytren’s Disease, which not only improves understanding of the complexity of the disease but also highlights the need for individualized treatment strategies. It highlights the critical balance between treatment efficacy and patient safety and advocates an integrated approach that takes into account the specific circumstances, disease stage, and lifestyle of the patient. This review calls for continued research into innovative treatments and early intervention strategies to improve prognosis and quality of life for patients while reducing the burden of Dupuytren’s Disease on healthcare systems.
Dissertation Institution Vilniaus universitetas.
Type Master thesis
Language English
Publication date 2024