Title Preventing intensive care unit acquired weakness: a literature review /
Translation of Title Preventing Intensive Care Unit Acquired Weakness: a Literature Review.
Authors Heinen, Luis Matthias
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Pages 23
Keywords [eng] Intensive Care Unit Acquired Weakness, ICUAW, ICUAW and Pathophysiology, ICUAW and Prevention, ICUAW and Mobilization, ICUAW and Physiotherapy, ICUAW and Nutrition, ICUAW and NMBAS, ICUAW and Pharmacological prevention, ICUAW and electrical stimulation, ICUAW, and NMES, Muscle wasting.
Abstract [eng] This thesis studies and presents strategies for preventing Intensive Care Unit Acquired Weakness in critically ill patients. This literature review aims to demonstrate standard practices for diagnosing muscle wasting and the up-to-date pathophysiology, divided into critical illness myopathy and critical illness neuropathy. Concerning prevention, mobilization/ physiotherapy, electrical stimulation, nutrition, and pharmacological treatment are addressed separately. This thesis concludes that prevention strategies focus on reducing the duration of Intensive Care Unit stays, early treatment of sepsis and infection, minimizing the use of neuromuscular blocking agents and sedatives, and ensuring adequate nutrition. Mobilization and physiotherapy are vital in preventing muscle wasting. Early mobilization shows potential in reducing the incidence of Intensive Care Unit-Acquired Weakness and increasing lower limb strength. However, the effectiveness of early versus regular mobilization remains under debate. The development of standardized protocols for early mobilization and technological advances, such as robotics and virtual reality, could enhance physiotherapy and rehabilitation in the Intensive Care Unit. While protein intake doesn’t seem to reduce the incidence of Intensive Care Unit Acquired Weakness, protein deficiency is common in Intensive Care Unit patients, and early enteral nutrition is recommended. Pharmacological interventions, including proteolytic inhibitors and autophagy regulators, show promise in preserving muscle mass and function. Drugs such as eicosapentaenoic acid and heat shock protein 72 inducers also show protective effects against muscle atrophy and weakness. Intensive insulin therapy has the most promising preventative potential. The most important keywords to find accurate literature were ICUAW, ICUAW and Prevention, and the significant preventative measure.
Dissertation Institution Vilniaus universitetas.
Type Master thesis
Language English
Publication date 2024