| Keywords [eng] |
Airway obstruction, CPAP, Obesity, Excessive Daytime Sleepiness, Phenotype treatment, Phenotyping, Sleep apnea, Sleep disorder, Stertor. |
| Abstract [eng] |
Obstructive Sleep Apnea (OSA) is a chronic disorder that significantly impacts the patient’s health—cardiovascular, mental, and other. It is a complex condition characterized by airway obstruction, leading to intermittent oxygen deprivation and associated sleep disturbances. OSA is a heterogeneous disorder, with variations in severity and the number of symptoms among patients. This diversity is also influenced by genetics, environment, and lifestyle choices. When discussing diversity, one also has to talk about the most common risk factors and phenotypes. Obesity is a health crisis, and in OSA, it is the most prevalent risk factor and has a phenotype. Lifestyle changes make a difference here, and every patient should have the chance to modify their obesity risk factor. Beyond obesity, there is a vast spectrum of complex phenotypes when it comes to identification and treatment. In this thesis, we will discuss the different phenotypes by highlighting risk factors, epidemiology, etiology, and the optimal treatment for each phenotype, with tailored interventions—invasive, noninvasive, or pharmaceuticals—for the best outcome for OSA patients. |
