| Abstract [eng] |
Colorectal cancer is the third most common oncological disease contributing to patient mortality. Due to improved diagnostics and preventive programs, the 5-year survival rate of patients has significantly increased, reaching 90%. However, metastatic liver disease greatly worsens patients' quality of life and survival rates. Unfortunately, about 15-20% of patients already have liver metastases at the time of diagnosis, and during treatment, 20-50% of patients will develop them. With the advent of modern liver surgery techniques combined with chemotherapy, the 5-year survival rate of patients with stage IV colorectal cancer with liver metastases has increased to 50%. The primary factor limiting the extent of liver resection is the postoperative liver volume, as inadequate volume can lead to liver failure, raising postoperative mortality to 80%. This doctoral dissertation analyses the treatment outcomes of colorectal cancer by comparing postoperative results in patients undergoing liver resection, considering chemotherapy treatment and the predicted residual liver volume. The study evaluates the dynamics of liver regenerative markers in the serum and their expression in histological images, assesses liver function in the postoperative period, examines the influence of liver regenerative markers on postoperative liver regeneration, and reviews the short- and long-term results of liver metastasis in patients treated at Vilnius University Hospital Santaros Clinics (VULSK). |
