| Abstract [eng] |
Atherosclerosis is the main cause of cardiovascular diseases. In the past decade, atherosclerosis has been defined as a chronic inflammatory process. The aim of the work: to make an overview of the epidemiology of atherosclerosis; explore changes in the concentration of the biochemical parameters of atherosclerosis such as total cholesterol (T-CH), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides (TAG) and of the inflammation parameter C-reactive protein (CRP) in the blood serum of healthy and ill people; and assess the role of those factors in the pathogenesis of atherosclerosis. Objectives of the work: to assess and compare changes in the concentration of the biochemical parameters of atherosclerosis and C-reactive protein in three age groups of relatively healthy people of mixed gender and two age groups of people diagnosed with myocardial infarction; to identify differences in the changes of the parameters of atherosclerosis in the same age groups of people who are relatively healthy and those diagnosed with myocardial infarction; and to assess the importance of the parameters of atherosclerosis for the early diagnosis of atherosclerosis. Material and methods. For the early diagnosis of atherosclerosis, the blood serum of 100 healthy people and 38 people diagnosed with myocardial infarction was tested for T-CH, HDL CH, LDL CH, TAG, and CRP. The entire test group was divided into three age groups: group I (31–40 years of age), group II (41–50 years of age), and group III (51–60 years of age). T-CH and HDL CH was tested using a CHOD-PAP method, TAG was tested by using a GOD-PAP method, the concentration of LDL CH was calculated directly by the analyser, and CRP was tested by applying an immunometric method. Results and conclusions. The results of the research demonstrated that there was an increased concentration of T-CH in the blood serum of relatively healthy people in the groups 41–50 years of age and 51–60 years of age, that an increased concentration of TAG was observed in all age groups, and that HDL CH and LDL Ch in all age groups was normal. An increased concentration of T-CH and LDL CH was identified for a larger number of women in all age groups, and an increased concentration of TAG was identified predominantly in men in the groups 31–40 years of age and 41–50 years of age and in women in the group 51–60 years of age. An increased concentration of CRP was identified in the blood serum of all relatively healthy men and women, whereas the concentration of HDL CH was normal. In the groups 41–50 years of age and 51–60 years of age diagnosed with myocardial infarction, concentrations of T-CH and TAG in blood serum exceeded the norm, and HDL CH and LDL CH were normal. CRP concentration in both age groups also exceeded the norm. It was identified that in the group 41–50 years of age diagnosed with myocardial infarction, the concentration of T-CH was statistically reliably higher than that of the same age group of relatively healthy people and that in the group 51–60 years of age, the concentrations of T-CH and TAG were statistically reliably higher in those diagnosed with myocardial infarction. Concentration of CRP in both age groups was statistically reliably higher in the blood serum of those diagnosed with myocardial infarction. T-CH, LDL CH, and TAG indicators and CRP concentration proved to be most informative in the early diagnosis of atherosclerosis. |
