| Abstract [eng] |
Staphylococcus aureus is one of the most common cause of infections. It’s relevant to know regional data of antimicrobial susceptibility to be able to prescribe effective drugs against S. aureus before knowing the suscpetibility of a specific culture. Objective. The analysis of Staphylococcus aureus’ susceptibility to antibiotics in Klaipėda’s children hospital in 2008-2009. In order to implement it, these tasks were established: 1) to analyse Staphylococcus aureus’ cultures isolated from clinical material in Klaipėda’s children hospital in 2008-2009; 2) to determine the antibiotic susceptibility of S. aureus’ cultures and perform the analysis of antibiotic susceptibility in 2008-2009. Methods. S. aureus was isolated by cultivating it on specific agars, catalase test, Gram staining; plasma coagulase test. Antibiotic susceptibility was determined by disk diffussion method; β-lactamase detection – by nitrocefin test; MRSA detection – by penicilin-binding protein (PBP’) late agglutination test. Statistical analysis was performed with program SPSS Statistics 17.0.' Results. In Klaipėda’s children hospital 1691 cultures of S. aureus were isolated in 2008-2009. Statistically relevant higher number of S. aureus’ cultures was isolated form children aged less than one year old. Most cultures were isolated from faeces (52.4%), pus (29.3%) and throat swabs (14.0%). 89.5% resistance to penicillin was determined. 20.5% and 0.7% of cultures were resistant and intermediate to erythromycin; 14.8% and 0.3% of cultures were resistant and intermediate to gentamycin; 0.2% of each of cultures were resistant (MRSA) and intermediate to oxacillin; 0.2% of cultures were resistant to cefazolin. The decrease of resistance to penicillin, erythromycin and gentamicin in 2009 was statistically significant. The increase of resistance to oxacillin and cefazolin in 2009 was statistically insignificant. Conclusions. In Klaipėda’s children hospital S. aureus mostly caused gastrointestinal, purulent and respiratory infections. Mostly affected children were younger than one year old. High resistance to penicillin was determined (it moderately matches data from other Lithuania’s hospitals). Resistance to other antibiotics (erythromycin, gentamicin, oxacillin, cefazolin) was lower than in other Lithuania’s hospitals. There is correlation between resistance to erythromycin and gentamicin. S. aureus resistance to penicillin, erythromycin and gentamicin decreased in 2009, to compare with 2008. While treating staphylococcal infection in Klaipėda’s children hospital oxacillin or cefazolin should prescribed as preliminary antibiotics; erythromycin and gentamicin should be antibiotics of second choice. |
