| Abstract [eng] |
SUMMARY Analysis of indicators of thyroid pathology in a district hospital Since the number of people suffering from thyroid pathology is increasing and thyroid dysfunction is being diagnosed at an increasingly younger age, the determination of LT4 and TSH concentration in blood serum is meaningful for the diagnosis of such diseases. Study objective. To evaluate changes in LT4 and TSH concentrations in blood serum in patients with thyroid pathology in a district hospital. Study goals. To evaluate changes in thyroid indicators and their significance for the evaluation of changes in LT4 and TSH hormone blood serum concentrations in patients, depending on the gender and age of the patients and the season. Material and methods. LT4 and TSH blood serum concentrations of 257 patients were tested in the laboratory of Rokiškis District Hospital. The study group involved 157 patients and the control group included 100 patients. Tests were performed with an Elecsys 1010 immunological analyser. Immunoenzyme assay of hormone blood serum concentration is designed to measure the level of free thyroxin (LT4) and thyrotropin (TSH) in human blood serum and plasma in vivo. These test methods are based on electrochemoluminescent immunological analysis. Free thyroxin is detected by concurrent assay, with specific anti-T4 antibody labelled with ruthenium complex. The test to detect TSH is based on the principle of a two-sided layered structure, using two specific monoclonal antibodies against human TSH. Results and conclusions. Results of the tests have revealed thyroid pathology in 40% of all tested patients. Hypothyrosis was more commonly diagnosed in the group of patients with thyroid diseases (34%). Statistically significant differences in LT4 and TSH levels between females and males were not discovered. Significantly higher incidence of thyroid pathology was observed in the group of tested patients aged 60 years and more (60%), and there was a decrease in LT4 concentration with age in the blood serum of ill people. A statistically significant decrease in blood serum LT4 concentration in ill people was found in spring. We established that the evaluation of LT4 and TSH concentration in blood serum is meaningful for the diagnosis of thyroid pathology. |
