| Abstract [eng] |
T wave alternans (TWA) is a beat-to-beat change in the amplitude or shape of T wave. TWA is one of potential biomarkers for ventricular arrhythmias and can be a sign of serious heart disease. Because there is no gold standard in TWA measuring, modifications of existing methods and new solutions are possible. Modified moving average method, proposed by Nearing and Verrier, is one of mostly used in medical practise, but can give misleading results then T waves is not properly aligned or T wave length and morphology changes because of heart rate variability. It is known, that some ventricular arrhythmias can cause heart rate variability, so this type of error is unwanted, because online TWA measuring can become one of sudden ventricular arrhythmias predictors in the near future. In this work, variuos time series alignment and similarity detection techniques were used to improve TWA measuring and this measure capabilities in heart disease diagnostic were analized. TWA analysis with simulated and real data from ECG databases was performed and potentional biomarker was found by using biomarkers combining method, proposed by Liu, Liu and Halabi. 57. |
