| Abstract [eng] |
Study‘s author: Alina Prodan Final medical biology Master‘s Degree study on „Application of Sigma Metrics for Quality Improvement in Laboratory of Clinical Chemistry“ Research adviser: Dr. Dalius Vitkus, Vilnius University, Medical Faculty, Department of Physiology, Biochemistry and Laboratory medicine. Reviewer: Assoc. Prof. Valerija Jablonskienė, Vilnius University, Medical Faculty, Department of Physiology, Biochemistry and Laboratory medicine Introduction. Modern laboratory is seeking to perform higher number of tests, using fewer funds while still achieving highest quality. Six Sigma methodology is a concept of basic quality improvement geared towards a process standardization. Sigma-metrics is used in Six Sigma quality management as a universal measure of quality. This quality assessment approach based on analysis of quality requirements. Statistical results of quality control analysis have been widely used for Master’s Degree study. Benefits of sigma-metrics for quality goals evaluation have been shown. The research presents quality requirement importance. Quality control procedures demonstrated significance for the quality of test. Aim of the study – to asess application of sigma-metrics for quality improvement in laboratory of clinical chemistry. Results. 12 of 20 researched analytes results did not meet the desirable quality goals. After applying sigma-metrics it was found, that ALAT and CK met the world class quality requirements. According to strict quality requirements (calcium - 2,4 %, chloride - 1,5 %, sodium - 0,9 %), sigma-metrics results were established: calcium and chloride - negative sigma, sodium- 0,6 sigma. After applying two control measurements, 8 of 20 study‘s results met the world class quality. After changing albumin‘s calibrator, albumin sigma results improved from negative to 3,9. For most analytes lowest sigma results were determined at low concentration levels. Conclusions. Most of the studied clinical chemistry analytes quality control samples did not meet the recommended analytical quality goals. After applying sigma-metric quantitatively evaluated analysis quality requirements. Because of strict quality requirements, sigma values are very low. After applying of two control measurements per day, sigma-metric results improved significantly. The importance of calibration material has been established. The results of sigma-metric showed the differences between most of studied analytes results, appearing as a result of proportional deviation. Keywords: quality control, sigmametric, quality requirements, clinical chemistry, quality goals. |
