| Abstract [eng] |
SUMMARY THE ANALYSIS OF LABORATORY INDICES OF TYPE I AND TYPE II DIABETES MELLITUS AT KLAIPEDA UNIVERSITY HOSPITAL Epidemiological studies suggest that number of patients with diabetes mellitus (DM) is increasing. Therefore, special attention is given to studies necessary to improve the diagnosis of DM and effective control of the disease. The aim: to analyse the peculiarities of laboratory indices of patients with type 1 and 2 DM. In order to reach this, the following goals were presented: to determine and evaluate type 1 and 2 DM’s dependency on patient’s age and sex; to assess the concentrations of glucose, glycosylated heamoglobin, creatinine, C-peptide in patient groups with type 1 and 2 DM and importance of laboratory indices for diagnosis of type 1 and 2 DM. Material and methods: 452 patients with I and II type MD were examined and hospitalized at Klaipeda University Hospital. Glucose concentration was determined by amperometric method, glycosylated heamoglobin (HbA1c) test was conducted by chromatographic method, C-peptide test was conducted by chemiluminescent immunometric method, creatinine test was conducted by immunoassay method. The results: 22.8 % of patients have type 1 DM, and 77.2 % - type 2. According to the statistically significant positive relationship, type 1 is more common among younger, and type 2 DM is more common among older patients. The statistically significant positive relationship between DM and the patient’s sex was determined: statistically, type 1 DM is more significant for men, and type 2– for women. Having evaluated the biochemical blood indices of patients with type 1 DM, a statistically significant negative relationship between the age and HBA1c in patients with type 1 DM was estimated. Statistically significant positive relationship was found between the age of patients with type 1 MD and creatinine concentration, between creatinine and C-peptide concentrations and between glucose concentration and HBA1c. Statistically significant positive relationship between creatinine concentration and the patients’ age with type 2 DM were determined. The relationships between C-peptide and creatinine, between C-peptide and glucose; between glucose and HBA1c; between HBA1c and sex of the patient in type 2 DM group was also statistically significant and positive. Conclusions and recommendations: it was determined that the blood glucose concentration test is the earliest and the most informative index for diagnosis of type 1 and 2 DM. Since the price of this research in comparison with the price of glycosylated heamoglobin concentration test is much lower, blood glucose concentration test is recommended as the most appropriate test for prevention of diabetes mellitus and its current control. |
